National and Subnational Incidence Trend of Bladder Cancer in Iran: Report of a 12-Year Period

Mohammad Reza Nowroozi; Erfan Amini; Ehsan Mosa Farkhani; Ali Nowroozi; Mohsen Ayati; Seyed Ali Momeni; Sepideh Mirzaei; Kiavash Hushmandi; Laleh Sharifi; Saied Bokaie

doi:10.5812/ijcm-127005

International Journal of Cancer Management

The Official Journal of Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences

Image Credit:Int J Cancer Manag

Outlines

Abstract
Acknowledgments
Footnotes
References
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https://doi.org/10.5812/ijcm-127005

National and Subnational Incidence Trend of Bladder Cancer in Iran: Report of a 12-Year Period

Author(s):

Mohammad Reza Nowroozi

¹,

Erfan Amini

¹,

Ehsan Mosa Farkhani

²,

Ali Nowroozi

¹,

Mohsen Ayati

¹,

Seyed Ali Momeni

¹,

Sepideh Mirzaei

³,

Kiavash Hushmandi

⁴,

Laleh Sharifi

^1,*,

Saied Bokaie

^4,**

1Uro-oncology Research Center, Tehran University of Medical Sciences, Tehran, Iran

2Department of Epidemiology, Faculty of Health, Mashhad University of Medical Sciences, Mashhad, Iran

3Department of Biology, Faculty of Science, Science and Research Branch, Islamic Azad University, Tehran, Iran

4Department of Food Hygiene and Quality Control, Division of Epidemiology and Zoonoses, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran

Corresponding Authors:

International Journal of Cancer Management:Vol. 16, issue 1; e127005

Published online:Jun 21, 2023

Article type:Research Article

Received:Apr 16, 2022

Accepted:Mar 11, 2023

How to Cite:Nowroozi MR, Amini E, Farkhani EM, Nowroozi A, Ayati M, et al. National and Subnational Incidence Trend of Bladder Cancer in Iran: Report of a 12-Year Period. Int J Cancer Manag. 2023;16(1):e127005. doi: https://doi.org/10.5812/ijcm-127005

Abstract

Background:

Bladder cancer is one of the most common cancers worldwide and also in Iran. Understanding of bladder cancer epidemiology is of great value for policymakers and assists in the prevention and early detection of the disease.

Objectives:

The aim of the present study was to report national and subnational incidence trends of bladder cancer in Iran between 2003 and 2015.

Methods:

This study investigated the age-standardized incidence rates (ASIRs) per annum of bladder cancer from 2003 to 2015 in Iran using the data from the cancer registration system of the Ministry of Health and Medical Education of Iran. The crude incidence rates were calculated by dividing incident cases by the country and province population, which were provided by the Statistic Center of Iran. Age standardization was performed using the WHO standard population, and ASIRs were compared by age, sex, and province.

Results:

The ASIR of bladder cancer increased from 8.35 in 2003 to 13.57 in 2015 in men. The ASIR of bladder cancer also showed a mild increase in females, 2.12 in 2003 versus 2.86 in 2015. The province of Yazd had the highest rate of bladder cancer in men, and West Azerbaijan had the highest rate for women (15.13 and 7.79 per 100,000), while Sistan va Baluchestan and Ilam had the lowest ASIRs for men and women (3.01 and 0.96 per 100,000, respectively).

Conclusions:

The increasing trend of bladder cancer incidence in Iran, despite the clear decreasing global trend accompanying to ongoing aging of the population highlights the diseases as a potential health problem in the upcoming years in Iran. Therefore, it is necessary for health organizations to implement effective research and control programs in the country to prevent further increases in disease burden.

Keywords

Urinary Bladder Neoplasms

1. Background

Bladder cancer is one of the most common cancers worldwide, especially in men that and in spite of all treatments, the mortality rate has remained high (1). According to the Global Burden of Disease report, there were 524,000 new bladder cancer cases and 229,000 bladder cancer deaths worldwide in 2019. The age-standard incidence rates (ASIRs) of bladder cancer were reported 1.4 - 31.9 per 100,000 population in different parts of the world. Monaco had the highest ASIRs in the world (31.9 per 100 000) followed by Lebanon (30.2 per 100,000) and San Marino (25.3 per 100,000) (2).

In Iran, bladder cancer is considered the most frequent urologic cancer in men and women (3). Different studies have evaluated the incidence rate of bladder cancer in Iran; ASIRs of bladder cancer varied from 2.1 to 17.7 per 100,000 in men (4, 5) and 0.4 to 4.1 per 100,000 in women (6, 7) in different provinces and different years. A recent systematic review and meta-analysis showed that the ASIRs of male and female bladder cancer are 10.92 and 2.80 per 100,000, respectively in Iran (8).

Incidence and mortality rates of bladder cancer vary globally and this may be due to genetic differences, population age, and exposure to risk factors i.e. smoking habits. The main histologic subtype of bladder cancer is urothelial carcinoma which includes more than 90% of all bladder cancers (9). Regardless of disease stage, bladder cancer is associated with high morbidity. Bladder cancer is non-muscle invasive in 70% to 80% of patients; however, the likelihood of recurrence is high in non-muscle invasive diseases and almost all patients require regular and life-long follow-up which imposes a remarkable financial burden on healthcare systems (10).

A thorough understanding of bladder cancer epidemiology is of great value for policymakers and assists in the prevention and early detection of the disease, especially in regions with high incidence or mortality rates. Epidemiological studies also may provide important information for studies that assess risk factors for cancer.

2. Objectives

In the present study, we aimed at reporting national and subnational incidence trends of bladder cancer in Iran between 2003 and 2015.

3. Methods

This descriptive-analytical study carried out on national and subnational data of pathology-confirmed cases of recorded bladder cancer that were by the Iranian National Cancer Registry of the Iran Ministry of Health and Medical Education has been developed systemically since 2000 using software-based data from all pathology centers with coverage of 100% of country provinces (11, 12). Since 2014, it has been developed by collecting clinical, paraclinical, and mortality data nationwide (13). In the Iranian cancer registry system, cancer types are coded according to the International Classification of Diseases for Oncology, third edition (ICD-O-3) (14), and the topography of cancers is determined based on the International Classification of Diseases, 10th edition (ICD-10) (15). In this system, bladder cancer is detectable by C67, the malignant neoplasm of the bladder (15). Statistics of new bladder cancer cases by each year and in each province were provided by recorded data from the National Cancer Management Secretariat of the Ministry of Health and Medical Education (16). In this study, the results were calculated and reported for the entire country and provinces based on the number of cases and ASIRs per 100,000 people per annum (in 18 age groups) for both sexes and by year and province. In this regard, the country’s population by men and women, as well as the population of the provinces, were obtained from the portal of the Iran Statistics Center. This center performs and reports the Iran population census every 5 years (17). Due to the unavailability of any population estimation in the interval between periods, the population of the nearest year was used for calculating Incidence rates.

Incidence rates were calculated directly and based on the standard population of the World Health Organization (WHO) using STATA software version 12. To simplify assessments of age-specific epidemiological rates through populations with diverse age structures, it is beneficial to determine short statistics which take away the effects of variation in age composition. For keeping the comparability of the incidence rates in different societies, WHO has introduced a new standard population as a basis to facilitate epidemiological research worldwide (18).

Due to the severe lack of data recording during the years 2010 to 2013, the available data did not have the necessary citation capability, so we decided to compensate for this shortcoming by performing a time series analysis for this period in support of a more precise presentation of national incidence trends.

For identifying a proper primary model sc and pac graphs were used. The comparison was done using the Likelihood ratio test (Lrtest). The autoregressive integrated moving average (ARIMA) model was used as the most common category of models for forecasting time series events (19). ARIMA (pdq) consists of components of autoregressive (p), the difference (d), and moving average (q) and in the case of having a seasonal pattern for a disease, are used as SARIMA (p d q) (P D Q) s. in this condition P, D, and Q components are same as the aforementioned model and s is the time corresponding to a data in the previous year.

4. Results

The number of incident bladder cancer cases in Iran was 39352 between 2003 and 2015 including 7044 (17.9%) women and 32308 (82.1%) men. The age-standardized incidence rate of bladder cancer in 2015 was 13.57 in men and 2.86 in women.

The numbers of incident cases, annual crude incidence rate, and ASIR for both sexes from 2003 to 2015 are demonstrated in Table 1. The age-specific incidence rate among men had a rising trend from 8.35 per 100,000 in 2003 to 13.57 in 2015. The incidence trend of bladder cancer in women also increased over the study period. The lowest women-adjusted incidence rate was 2.12 per 100,000 in 2003 and the highest was 3.78 per 100,000 in 2008.

Table 1.Number, Crude Incidence and Age-standardized Incidence Rate per 100,000 of Bladder Cancer from 2003 to 2015 in Iran

Year and Gender	Number of Cases	Crude Incidence Rate	ASIR
2003
Male	2263	6.63	8.35
Female	482	1.49	2.12
2004
Male	2722	7.84	9.90
Female	579	1.76	2.49
2005
Male	3248	8.99	11.30
Female	689	2.01	2.86
2006
Male	3347	9.30	11.66
Female	705	2.06	2.99
2007
Male	3617	10.05	13.03
Female	781	2.29	3.32
2008
Male	3957	10.99	14.42
Female	883	2.58	3.78
2009
Male	3764	9.57	12.59
Female	837	2.44	3.28
2010 ^a
Male	3780	9.97	12.89
Female	859	2.30	2.70
2011 ^a
Male	3565	9.40	11.81
Female	768	2.06	2.71
2012 ^a
Male	3606	9.40	12.01
Female	689	1.82	2.14
2013 ^a
Male	3604	9.29	11.76
Female	645	1,69	2.17
2014
Male	4776	12.37	14.30
Female	1041	2.47	2.97
2015
Male	4615	11.82	13.57
Female	1047	2.72	2.86

Abbreviations: ASIR, age-standardized incidence rate.

^a Results are provided by time series model

The incidence rate of bladder cancer increased with age in both sexes and the highest ASIR of bladder cancer was observed in the age group of 80 to 84 years (Figures 1 and 2).

Figure 1.

Age-standardized incidence rates (ASIRs) per 100,000 of female bladder cancer based on age groups during 2003 to 2015 in Iran

Figure 2.

Age-standardized incidence rates (ASIRs) per 100,000 of male bladder cancer based on age groups during 2003 to 2015 in Iran

The highest ASIR of male bladder cancer was related to Yazd (15.13 per 100,000) followed by Isfahan (14.59 per 100,000), Gilan (14.12 per 100,000), and Fars (14.00 per 100,000) whereas the lowest one was related to Sistan va Baluchestan and Ilam (3.01 and 4.58 per 100,000, respectively). In women, the highest ASIR was related to West Azerbaijan (7.79 per 100000) followed by Bushehr (3.69 per 100000), Fars (3.33 per 100000), and Kerman (3.30 per 100000). Also, our result showed that the lowest ASIR of female bladder cancer was related to Ilam, Sistan va Baluchestan and Hormozgan (0.96, 1.26 and 1.48 per 100000, respectively).

During the years of study, the highest peaks of women’s bladder cancer incidence rate occurred in Bushehr (6.19 per 100,000 in 2014), East Azerbaijan (6.19 per 100,000 in 2008), and Khuzestan (5.17 per 100,000 in 2008). Moreover, Kerman (27.3 per 100,000 in 2014 and 22.4 per 100,000 in 2015), Tehran (21.24 per 100,000 in 2008), as well as Gilan (20.12 per 100,000 in 2008) had the highest incidence rates of men’s bladder cancer in Iran (Table 2 and Figure 3). Analyzing the geographical distribution of new bladder cancer cases indicated that Bushehr province presented the highest ASIR in females in 2015 (6.83 per 100,000), while the highest ASIR in males in the same year was observed in Kerman province (22.40 per 100,000) (Figures 4 and 5).

Table 2.Age-standardized Incidence Rates per 100,000 of Bladder Cancer in Provinces of Iran from 2003 to 2015

Province and Sex	2003	2004	2005	2006	2007	2008	2009	2010 ^a	2011 ^a	2012 ^a	2013 ^a	2014	2015	Total
Ardabil
Male	8.44	10.56	6.32	11.66	7.45	9.92	9.92	9.1	9.65	9.55	9.93	10.60	11.80	9.63
Female	1.81	1.90	1.79	2.99	1.02	3.22	2.15	2.13	2.5	2.26	2.36	2.33	3.00	2.249
Bushehr
Male	5.88	7.51	8.20	9.70	7.44	11.57	16.06	11.69	13.11	13.62	15.08	18.50	19.00	11.54
Female	2.73	2.52	2.30	2.67	4.50	3.28	3.56	3.78	3.54	3.63	3.99	4.80	6.83	3.69
Chaharmahal Bakhtiari
Male	4.54	7.89	8.65	11.35	15.67	16.04	11.76	14.49	14.1	13.45	14.15	14.90	6.90	10.86
Female	0.36	3.99	1.91	1.90	2.70	3.20	1.38	2.43	2.34	2.05	2.33	2.60	2.37	2.27
East Azerbaijan
Male	2.46	11.2	2.95	3.00	15.75	19.64	15.92	17.1	17.55	16.86	16.07	13.80	13.8	10.95
Female	0.35	1.75	0.85	0.65	4.88	6.19	4.46	5.18	5.28	4.97	4.49	3.22	3.30	2.85
Fars
Male	10.85	10.45	13.49	11.62	17.89	13.70	15.68	15.76	15.05	15.49	15.41	15.70	16.6	14.00
Female	2.68	2.42	2.49	2.98	4.45	3.70	4.96	4.37	4.34	4.56	4.11	3.42	2.91	3.33
Ghazvin
Male	6.36	5.99	7.83	7.17	10.32	10.72	7.21	9.42	9.12	8.58	10.37	13.40	12.10	9.01
Female	1.55	1.67	2.13	1.46	3.18	2.79	1.78	2.58	2.38	2.25	2.61	3.19	0.81	2.062
Gilan
Male	7.67	11.52	13.82	14.51	15.93	20.12	16.55	17.53	18.07	17.38	16.12	12.90	14.10	14.12
Female	1.47	2.14	3.49	4.74	4.88	4.20	2.46	3.85	3.5	3.27	2.99	2.19	2.95	3.17
Golestan
Male	5.75	4.84	6.34	7.61	4.30	9.23	8.31	7.28	8.27	7.95	8.81	10.20	7.20	7.09
Female	3.14	2.37	2.17	2.80	0.85	1.65	2.20	1.57	1.81	1.86	1.9	2.04	4.27	2.39
Hamedan
Male	7.84	9.13	12.20	12.54	16.92	14.37	11.20	14.16	13.24	12.87	12.9	12.60	11.70	12.05
Female	1.08	1.28	3.24	2.11	2.16	2.18	2.15	2.16	2.16	2.16	2.28	2.51	1.96	2.07

Hormozgan
Male	2.71	7.87	3.79	3.95	6.26	5.45	4.13	5.28	4.95	4.79	6.01	8.30	10.10	5.84
Female	0.92	1.17	0.23	1.21	2.17	1.93	2.04	2.05	2.01	2.03	2.17	2.46	1.23	1.48
Ilam
Male	2.33	3.75	2.28	4.48	5.49	4.69	5.45	5.21	5.12	5.26	5.63	6.50	6.30	4.58
Female	0.49	1.92	0.49	0.63	1.28	0.96	0.47	0.9	0.78	0.72	1.08	1.75	0.67	0.96
Isfahan
Male	7.64	12.37	11.78	14.43	16.83	16.33	15.95	16.37	16.22	16.18	16.53	17.20	18.80	14.59
Female	2.11	3.13	2.53	3.13	3.74	3.42	3.11	3.42	3.32	3.28	3.38	3.55	3.72	3.16
Kerman
Male	6.29	7.73	9.71	9.41	11.17	13.20	14.66	13.01	13.62	13.76	18.23	27.30	22.40	13.54
Female	2.07	2.40	1.76	3.91	3.31	3.27	4.35	3.64	3.75	3.92	4.01	4.37	4.26	3.3
Kermanshah
Male	14.62	10.61	11.03	9.32	12.64	13.55	15.74	13.98	14.42	14.71	13.25	10.60	12.40	12.28
Female	3.50	2.08	2.24	2.64	3.17	3.90	4.39	3.82	4.04	4.08	3.2	1.49	2.52	2.88
Khorasan Razavi
Male	6.65	7.73	5.78	9.88	10.53	12.43	9.99	10.98	11.13	10.7	11.75	13.40	10.80	9.69
Female	2.12	2.80	1.45	3.07	3.74	3.60	3.04	3.46	3.37	3.29	3.15	2.79	2.63	2.80
Khuzestan
Male	7.22	6.83	7.11	9.84	8.90	11.71	10.52	10.38	10.87	10.59	11.49	13.00	13.90	9.89
Female	2.56	1.56	2.33	3.52	2.37	5.17	2.79	3.44	3.8	3.34	3.43	3.13	2.96	2.93
Kohkilouye va Boyer Ahmad
Male	1.30	10.54	7.74	11.91	8.99	9.18	8.98	9.05	9.07	9.03	10.1	12.20	12.10	9.21
Female	0.00	3.19	0.40	0.25	2.66	1.00	1.93	1.86	1.6	1.8	2.92	5.36	2.10	1.87
Kurdistan
Male	5.81	8.10	12.24	11.76	10.02	11.41	10.27	10.57	10.75	10.53	10.36	9.80	10.70	10.01
Female	3.58	2.52	2.24	1.95	3.22	3.28	3.22	3.24	3.25	3.24	2.65	1.47	3.59	2.78
Lorestan
Male	5.40	9.52	8.64	8.24	10.39	13.03	12.50	11.97	12.5	12.32	11.01	8.20	8.80	9.41
Female	0.42	2.62	2.71	2.40	3.22	3.96	2.93	3.37	3.42	3.24	2.64	1.26	3.75	2.58
Markazi
Male	7.36	9.83	10.15	9.68	11.63	11.17	16.06	12.95	13.39	14.14	12.44	9.80	12.60	10.92
Female	1.70	1.81	2.12	2.16	3.30	2.85	2.72	2.96	2.84	2.84	2.49	1.78	1.59	2.22
Mazandaran
Male	7.91	10.72	10.83	8.70	8.16	8.81	11.19	9.39	9.8	10.12	10.17	10.60	11.40	9.81
Female	1.19	1.89	2.46	3.45	1.80	2.67	1.80	2.09	2.19	2.03	2.22	2.46	2.37	2.23
North Khorasan
Male	6.65	7.73	3.77	5.00	5.42	6.59	4.87	5.63	5.7	5.4	7.06	10.10	10.90	6.78
Female	2.12	2.80	1.00	1.23	1.89	1.99	1.29	1.72	1.67	1.56	2.38	3.90	1.91	2.01
Qom
Male	3.70	10.46	7.30	6.82	9.49	9.80	4.52	7.94	7.42	6.63	7.02	5.91*	6.89*	7.44
Female	2.31	0.46	4.73	1.87	0.94	1.30	1.60	1.28	1.39	1.42	1.41	1.24*	1.36*	1.89
Semnan
Male	5.04	9.00	10.75	14.79	10.76	16.50	10.72	12.66	13.29	12.22	13.01	13.50	19.10	12.24
Female	0.54	3.03	5.03	3.32	3.91	3.42	3.48	3.6	3.5	3.53	3.12	2.33	2.21	3.03
Sistan va Baluchestan
Male	1.62	1.24	2.19	2.80	2.41	1.96	2.27	2.21	2.15	2.21	3.59	6.40	6.20	3.01
Female	0.39	0.92	0.72	0.50	1.19	1.06	1.04	1.1	1.07	1.07	1.76	3.14	2.41	1.26
South Khorasan
Male	6.65	7.73	10.29	9.61	0.30	8.75	7.00	5.35	7.03	6.46	8.16	11.00	8.80	7.79
Female	2.12	2.80	7.96	2.44	0.49	5.66	1.46	2.54	3.22	2.41	3.17	3.90	2.55	3.26
Tehran
Male	15.20	7.70	10.03	9.41	9.14	21.24	15.79	15.39	17.47	16.22	16.86	16.9	14.20	13.29
Female	4.01	2.26	2.65	2.00	2.42	5.05	4.54	4	4.53	4.36	4.07	3.33	2.64	3.21
West Azerbaijan
Male	8.48	10.25	11.08	10.89	13.37	9.97	10.60	11.31	10.63	10.85	14.06	20.70	15.60	12.33
Female	1.47	2.72	2.85	2.49	2.02	1.94	4.00	2.65	2.86	3.17	3.49	4.42	3.25	2.793
Yazd
Male	9.85	10.26	11.24	13.91	16.09	15.46	17.05	16.2	16.24	16.5	19.21	24.90	17.40	15.13
Female	3.59	2.53	3.64	2.09	3.90	3.80	4.24	3.98	4.01	4.08	3.74	3.13	3.16	3.34
Zanjan
Male	7.00	8.79	9.51	8.54	9.28	9.60	8.74	9.21	9.18	9.04	9.84	11.30	10.80	9.28
Female	2.04	2.77	1.10	1.98	1.90	3.19	1.20	2.1	2.16	1.82	1.86	1.60	0.94	1.88

Abbreviation: ASIR, age-standardized incidence rate.

^a Results are provided by time series model.

Figure 3.

Age-standardized incidence rates (ASIRs) per 100,000 of bladder cancer in provinces of Iran during 2003 - 2015

Age-standardized incidence rates (ASIRs) per 100,000 of male bladder cancer among provinces of Iran in 2015 (<a href="#A127005REF20">20</a>)

Figure 4.

Age-standardized incidence rates (ASIRs) per 100,000 of male bladder cancer among provinces of Iran in 2015 (20)

Age-standardized incidence rates (ASIRs) of female bladder cancer among provinces of Iran in 2015 (<a href="#A127005REF20">20</a>)

Figure 5.

Age-standardized incidence rates (ASIRs) of female bladder cancer among provinces of Iran in 2015 (20)

5. Discussion

While cancer is the third leading cause of mortality in Iran (21), few epidemiological studies have been conducted related to this issue. In this study, we used data from Iran’s Ministry of Health and Medical Education to present the most recent trends of bladder cancer incidence in the country and its provinces from 2003 to 2015.

We showed that the ASIR of bladder cancer increased from 8.35 in 2003 to 13.57 in 2015 among men. ASIR of bladder cancer also showed a slight increase in females (2.12 in 2003 versus 2.86 in 2015), which indicates that the rise of bladder cancer ASIR in men (63%) has been much higher than in women (35%) through the years of the study. In 2015, the ASIR of bladder cancer among Iranian males and females was 13.57 and 2.86, respectively. Although the incidence rate of bladder cancer in men in Iran is higher than in Asian countries such as Bhutan (1.1 in 100,000), Vietnam (1.8 in 100,000), and Mongolia (2.2 in 100,000), this incidence in comparison to West Asian countries and Iran’s neighbors including Lebanon (29.1 per 100,000), Turkey (28.7 per 100,000) and Armenia (27.3 per 100,000) are significantly lower (22). However, the incidence rate of bladder cancer is comparable to the global average (11.81 in men and 2.69 in women) but illustrating the incidence trend shows an opposite development of this cancer in our country. Although ASIR of bladder cancer incidence in Iran has increased in years 2003 to 2015 among both men and women, the global trend of bladder cancer has declined globally from 1990 to 2016 (1).

During the years of the study, the highest ASIRs of men and women with bladder cancer (14.42 and 3.78 per 100,000, respectively) were observed in 2008. Bladder cancer in both sexes occupied the fifth rank of all cancers and bladder cancer in men was the third cancer in Iran (16). In the interpretation of our results, we found that in 2008, the incidence of bladder cancer in women and men in Tehran, Gilan, and East Azerbaijan provinces had a sharp increase compared to the previous and subsequent years. For example, bladder cancer in men in 2008 was 21.24 per 100,000 people, while it was 9.14 per 100,000 people in the previous year and 15.79 per 100,000 people in the following year, which indicates a sharp increase in a short time. To explain the reason for these increases, in addition to checking the accuracy of information registration, more detailed investigations are needed, especially regarding environmental factors in these regions.

Our results showed that the incidence rate of bladder cancer is higher in men as only 17.8% of all bladder cancers occurred in women. This is similar to global numbers where approximately 23% of new cases of bladder cancer are females (1). Moreover, we showed that the incidence of bladder cancer is higher in the older population. Iranian males and females have life expectancies of 81.6 and 71.6, respectively, which have been increasing constantly over the last 40 years (23). If the trend continues, the incidence rate of bladder cancer increases may increase further due to the aging of the population. Interestingly, our hypothesis is supported by a recent study by Roshandel et al. that predicts an overall increase in the number of new cases with bladder cancer in Iran including a 26.2% rising by 2025 (13).

Assessing cancer incidence based on the different geographical distributions has a significant impact on the formation of a new hypothesis that can not only indicate the potential risk factors of bladder cancer but can also lead to the emergence of methods of prevention or screening of high-risk individuals. The incidence in a particular area changes over time while the actual increase in cancer in an area can be explained by the increased exposure to a variety of carcinogens, it should be noted that early screening programs can lead to a false increase in cancer rates due to early detection of cancer (24).

Notably, the highest incidence rates of bladder cancer in Iran are reported in Kerman province (27.30 per 100,000) in 2014 which could compatible with the prevalence of opium addiction in this area. Investigating the risk factors of bladder cancer in Iran by Shakhssalim et al. and Ghadimi et al. revealed that some lifestyle factors, such as opium consumption, may play an important role in the development of bladder cancer in our region (25, 26). Opium is one of the most frequently used drugs that have been widespread from hundred years ago in Iran and unfortunately, the number of opium abusers has increased by about 8% annually in the country (27). North and southern regions of the country are reported as high-risk areas in terms of opium consumption (28, 29). It has been found in Iran that the use of opium leads to an increased risk of bladder cancer by 4.60 times (30). Our results emphasize the need for more research and supervision of addiction control in these areas.

Our results found the high-risk provinces in Iran; the highest ASIR of bladder cancer in men is related to Yazd (15.13 per 100,000) followed by Isfahan (14.59 per 100,000), and Gilan (14.12 per 100,000) and the highest ASIR of bladder cancer in women is related to Bushehr (3.69 per 100,000) followed by Yazd (3.34 per 100,000) and Fars (3.33 per 100,000) showing the spatial distribution of bladder cancer in hot and arid regions in Iran. Iran is a vast country with diverse kinds of climates including mild and wet on the northern coast, continental and arid in the central plateau, cold in the high mountains, desert hot in the southeast and on the southern coast. The higher incidence of bladder cancer in arid and hot areas of Iran with a lower density of population underscores the need for further ecological investigations to find the associated risk factors. High temperature, ultraviolet radiation, soil, and water component are the risk factors that may be effective in the higher incidence rate of bladder cancer.

Iran is a developing country and as mentioned previously, its population is getting older. Therefore, bladder cancer incidence is likely to rise, as older age groups are more likely to be diagnosed with bladder cancer. Also, higher age might worsen the complications and burden of the disease.

Smoking and increased fasting plasma glucose play a crucial role in the burden of bladder cancer (2). However, some important risk factors of bladder cancer such as smoking and obesity (31) are modifiable and the importance of educational and preventive strategies cannot be overstated. Inequality in health resource allocation may also contribute to varying incidence rates in different provinces; for instance, lower ASIRs of bladder cancer in Sistan and Balouchestan, and Ilam can be due to inequity in diagnostic facilities in these provinces however developing precise investigations in this regard is necessary.

5.1. Conclusions

The increasing trend of bladder cancer incidence in Iran which is despite of clear decreasing global trend accompanying to ongoing aging of the population highlights the disease as a potential health problem in the upcoming years in Iran. The higher incidence of bladder cancer in arid and hot areas of Iran underscores the need for further epidemiological investigations to find the associated risk factors. Therefore, it is necessary for health organizations to implement effective research and control programs including public awareness programs to avoid smoking and drugs, follow a healthy diet, timely treatment of urinary infections, avoid certain chemical exposure at the workplace as well as provide the necessary facilities for timely diagnosis and rapid treatment of bladder cancer in all parts of the country to prevent further increases in the disease burden.

Acknowledgments

Footnotes

Authors' Contribution: M. R. N. and S. B. conceived and designed the evaluation and drafted the manuscript. E.A. participated in designing the evaluation, performed parts of the statistical analysis and helped to draft the manuscript. E. H. M, A. N. and M. A. re-evaluated the clinical data, revised the manuscript and performed the statistical analysis and revised the manuscript. S. R. and S. A. M. collected the clinical data, interpreted them and revised the manuscript. S. M., K. H., and L. S. re-analyzed the clinical and statistical data and revised the manuscript. All authors read and approved the final manuscript.
Conflict of Interests: This research was funded by Tehran University of Medical Sciences. No financial interest is reported. The authors do not have any share in any company relevant to this paper and declare no competing or conflict of interest.
Ethical Approval: Code: IR.TUMS.VCR.REC.1397.760.
Funding/Support: This research project was supported and funded by Tehran University of Medical Sciences (Grant Number: 97-03-114-40709).

References

1.
Ebrahimi H, Amini E, Pishgar F, Moghaddam SS, Nabavizadeh B, Rostamabadi Y, et al. Global, Regional and National Burden of Bladder Cancer, 1990 to 2016: Results from the GBD Study 2016. J Urol. 2019;201(5):893-901. [PubMed ID: 30676477]. https://doi.org/10.1097/JU.0000000000000025.
2.
Safiri S, Kolahi AA, Naghavi M, Global Burden of Disease Bladder Cancer C. Global, regional and national burden of bladder cancer and its attributable risk factors in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease study 2019. BMJ Glob Health. 2021;6(11). [PubMed ID: 34844997]. [PubMed Central ID: PMC8634015]. https://doi.org/10.1136/bmjgh-2020-004128.
3.
Basiri A, Shakhssalim N, Jalaly NY, Miri HH, Partovipour E, Panahi MH. Difference in the incidences of the most prevalent urologic cancers from 2003 to 2009 in Iran. Asian Pac J Cancer Prev. 2014;15(3):1459-63. [PubMed ID: 24606483]. https://doi.org/10.7314/apjcp.2014.15.3.1459.
4.
Rafiemanesh H, Mehtarpoor M, Mohammadian-Hafshejani A, Salehiniya H, Enayatrad M, Khazaei S. Cancer epidemiology and trends in Sistan and Baluchestan province, Iran. Med J Islam Repub Iran. 2015;29:254. [PubMed ID: 26793645]. [PubMed Central ID: PMC4715419].
5.
Fateh M, Emamian MH. Cancer incidence and trend analysis in shahroud, iran, 2000 - 2010. Iran J Cancer Prev. 2013;6(2):85-94. [PubMed ID: 25250116]. [PubMed Central ID: PMC4142911].
6.
Mehrbani D, Tabeei SZAD, Heydari ST, Shamsina SJ, Shokrpour N, Amini M, et al. Cancer occurrence in Fars province, southern Iran. Iran Red Crescent Med J. 2008.
7.
Talaiezadeh A, Tabesh H, Sattari A, Ebrahimi S. Cancer incidence in southwest of iran: first report from khuzestan population-based cancer registry, 2002-2009. Asian Pac J Cancer Prev. 2013;14(12):7517-22. [PubMed ID: 24460327]. https://doi.org/10.7314/apjcp.2013.14.12.7517.
8.
Hassanipour S, Delam H, Fathalipour M, Sharifi M, Abdzadeh E, Fouladseresht H, et al. The incidence of bladder cancer in Iran: a systematic review and meta-analysis. World Cancer Research Journal. 2019;6(e1222):1-10.
9.
Sakai I, Miyake H, Harada K, Hara I, Inoue TA, Fujisawa M. Analysis of factors predicting intravesical recurrence of superficial transitional cell carcinoma of the bladder without concomitant carcinoma in situ. Int J Urol. 2006;13(11):1389-92. [PubMed ID: 17083389]. https://doi.org/10.1111/j.1442-2042.2006.01562.x.
10.
Harada K, Sakai I, Kurahashi T, Muramaki M, Yamanaka K, Hara I, et al. Clinicopathological features of recurrence after radical cystectomy for patients with transitional cell carcinoma of the bladder. Int Urol Nephrol. 2006;38(1):49-55. [PubMed ID: 16502052]. https://doi.org/10.1007/s11255-005-2944-8.
11.
National Cancer Management Secretariat. [National Cancer Management Secretariat]. Tehran, Iran: Ministry of Health, Treatment and Medical Education of the Islamic Republic of Iran; 2020, [cited 18 Feb 2020]. Persian. Available from: https://cancer.behdasht.gov.ir/.
12.
Roshandel G, Ghanbari-Motlagh A, Partovipour E, Salavati F, Hasanpour-Heidari S, Mohammadi G, et al. Cancer incidence in Iran in 2014: Results of the Iranian National Population-based Cancer Registry. Cancer Epidemiol. 2019;61:50-8. [PubMed ID: 31132560]. https://doi.org/10.1016/j.canep.2019.05.009.
13.
Roshandel G, Ferlay J, Ghanbari-Motlagh A, Partovipour E, Salavati F, Aryan K, et al. Cancer in Iran 2008 to 2025: Recent incidence trends and short-term predictions of the future burden. Int J Cancer. 2021;149(3):594-605. [PubMed ID: 33884608]. https://doi.org/10.1002/ijc.33574.
14.
World Health Organization. International classification of diseases for oncology (ICD-O). 3rd, 1st revision ed. Geneva, Switzerland: World Health Organization; 2013. p. viii-published by the Petrov Research Institute of Oncology, Federal State Budget Institution of the Ministry of Healthcare of the Russian Federation. Spanish-1ed-est-2ed-gre-2ed-Russian-2ed-slo-2ed-Polish-3ed- published by the Center of Oncology in PolandSlovenian – 3rd ed, Chinese – 3rd ed, German – 3rd ed, Czech – 3rd ed, Dutch – 3rd ed,Portuguese – 3rd ed,Finnish – 3rd ed, Japanese – 3rd ed, Korean – 3rd ed, Romanian – 3rd ed, Turkish – 3rd ed. The Turkish version is published by the Ministry of Health of Turkey. The Japanese version is published by the Ministry of Health, Labour and Welfare of Japan. The Spanish version is published by the Ministerio de Sanidad de España.
15.
World Health Organization. International statistical classification of diseases and related health problems. Geneva, Switzerland: World Health Organization; 2019, [cited 16 May 2019]. Available from: https://icd.who.int/browse10/2016/en#/C67.
16.
National Cancer Management Secretariat. [National report of the National Cancer Registry Program]. Tehran, Iran: Ministry of Health, Treatment and Medical Education of the Islamic Republic of Iran; 2020, [cited 18 Feb 2020]. Persian. Available from: https://cancer.behdasht.gov.ir/%D8%A7%D9%86%D8%AA%D8%B4%D8%A7%D8%B1%D8%A7%D8%AA.
17.
Statistic Center of Iran. Population and Housing Censuses. Tehran, Iran: Statistic Center of Iran; 2020, [cited 13 Jan 2020]. Available from: https://www.amar.org.ir/english/Population-and-Housing-Censuses.
18.
Ahmad OB, Boschi-Pinto C, Lopez AD, Murray C, Lozano R, Inoue M. Age standardization of rates: a new WHO standard. 9. Geneva, Switzerland: World Health Organization; 2001.
19.
Soyiri IN, Reidpath DD. Evolving forecasting classifications and applications in health forecasting. Int J Gen Med. 2012;5:381-9. [PubMed ID: 22615533]. [PubMed Central ID: PMC3355849]. https://doi.org/10.2147/IJGM.S31079.
20.
Ministry of Health. [National report of registration of cancer cases in 2015]. Tehran, Iran: Ministry of Health, Treatment and Medical Education of the Islamic Republic of Iran; 2015. Persian.
21.
Saadat S, Yousefifard M, Asady H, Moghadas Jafari A, Fayaz M, Hosseini M. The Most Important Causes of Death in Iranian Population; a Retrospective Cohort Study. Emerg (Tehran). 2015;3(1):16-21. [PubMed ID: 26512364]. [PubMed Central ID: PMC4614603].
22.
Pakzad R, Mohammadian-Hafshejani A, Mohammadian M, Pakzad I, Safiri S, Khazaei S, et al. Incidence and Mortality of Bladder Cancer and their Relationship with Development in Asia. Asian Pac J Cancer Prev. 2015;16(16):7365-74. [PubMed ID: 26514538]. https://doi.org/10.7314/apjcp.2015.16.16.7365.
23.
Ebrahimi N, Mehdipour P, Mohebi F, Ghanbari A, Azmin M, Farzadfar F. Improved Population Health in Iran from 1979 to 2019; Decreasing Mortality Rates and Increasing Life Expectancy. Arch Iran Med. 2020;23(2):61-8. [PubMed ID: 32061067].
24.
Jemal A, Center MM, Ward E, Thun MJ. Cancer occurrence. Methods Mol Biol. 2009;471:3-29. [PubMed ID: 19109772]. https://doi.org/10.1007/978-1-59745-416-2_1.
25.
Shakhssalim N, Hosseini SY, Basiri A, Eshrati B, Mazaheri M, Soleimanirahbar A. Prominent bladder cancer risk factors in Iran. Asian Pac J Cancer Prev. 2010;11(3):601-6. [PubMed ID: 21039023].
26.
Ghadimi T, Gheitasi B, Nili S, Karimi M, Ghaderi E. Occupation, smoking, opium, and bladder cancer: A case-control study. South Asian J Cancer. 2015;4(3):111-4. [PubMed ID: 26942139]. [PubMed Central ID: PMC4756483]. https://doi.org/10.4103/2278-330X.173174.
27.
Akbari M, Naghibzadeh-Tahami A, Khanjani N, Baneshi MR, Kamali E, Hesampour M, et al. Opium as a Risk Factor for Bladder Cancer: A Population-based Case-control Study in Iran. Arch Iran Med. 2015;18(9):567-71. [PubMed ID: 26317596].
28.
Ziaaddini H, Ziaaddini MR. The Household Survey of Drug Abuse in Kerman, Iran. J Applied Sci. 2005;5(2):380-2. https://doi.org/10.3923/jas.2005.380.382.
29.
Nakhaee N, Divsalar K, Meimandi MS, Dabiri S. Estimating the prevalence of opiates use by unlinked anonymous urine drug testing: a pilot study in Iran. Subst Use Misuse. 2008;43(3-4):513-20. [PubMed ID: 18365947]. https://doi.org/10.1080/10826080701772348.
30.
Hosseini SY, Safarinejad MR, Amini E, Hooshyar H. Opium consumption and risk of bladder cancer: A case-control analysis. Urol Oncol. 2010;28(6):610-6. [PubMed ID: 19110453]. https://doi.org/10.1016/j.urolonc.2008.10.016.
31.
Cumberbatch MGK, Jubber I, Black PC, Esperto F, Figueroa JD, Kamat AM, et al. Epidemiology of Bladder Cancer: A Systematic Review and Contemporary Update of Risk Factors in 2018. Eur Urol. 2018;74(6):784-95. [PubMed ID: 30268659]. https://doi.org/10.1016/j.eururo.2018.09.001.

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Author(s):

Mohammad Reza Nowroozi:[PubMed][Scholar]
Erfan Amini:[PubMed][Scholar]
Ehsan Mosa Farkhani:[PubMed][Scholar]
Ali Nowroozi:[PubMed][Scholar]
Mohsen Ayati:[PubMed][Scholar]
Seyed Ali Momeni:[PubMed][Scholar]
Sepideh Mirzaei:[PubMed][Scholar]
Kiavash Hushmandi:[PubMed][Scholar]
Laleh Sharifi:[PubMed][Scholar]
Saied Bokaie:[PubMed][Scholar]

The Official Journal of Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences

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National and Subnational Incidence Trend of Bladder Cancer in Iran: Report of a 12-Year Period

Abstract

Background:

Objectives:

Methods:

Results:

Conclusions:

1. Background

2. Objectives

3. Methods

4. Results

5. Discussion

5.1. Conclusions

Acknowledgments

Footnotes

References

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