A Study of Contractility of Proximal Surgical Margin in Esophageal Cancer

Jalaluddin Khoshnevis; Afshin Moradi; Eznollah Azargashb; Barmak Gholizade; Mohammad Reza Sobhiyeh

International Journal of Cancer Management

The Official Journal of Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences

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Abstract
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A Study of Contractility of Proximal Surgical Margin in Esophageal Cancer

Author(s):

Jalaluddin Khoshnevis^1,*,

Afshin Moradi²,

Eznollah Azargashb³,

Barmak Gholizade¹,

Mohammad Reza Sobhiyeh¹

1Cancer Research Center, Shahid Beheshti University of Medical Sciences, Dept. of General and Vascular Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

3Cancer Research Center, Shahid Beheshti University of Medical Sciences, Dept. of Health and Social Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

International Journal of Cancer Management:Vol. 6, issue 1; e80380

Published online:Mar 30, 2013

Article type:Research Article

Received:Sep 22, 2012

Accepted:Nov 18, 2012

How to Cite:Jalaluddin KhoshnevisAfshin MoradiEznollah AzargashbBarmak GholizadeMohammad Reza SobhiyehA Study of Contractility of Proximal Surgical Margin in Esophageal Cancer.Int J Cancer Manag.6(1):e80380.

Abstract

Background: The marginal length from main tumor in esophageal cancer is a considerable issue regarding surgical management and adjuvant treatment; so we decided to study the contractility effect on the proximal surgical margin after immersing it in10% buffered formalin as a fixative.

Methods: The proximal marginal length of ten sequential patients with esophageal cancer who underwent transhiatal esophagectomy were studied, on the operating table as fresh specimens, immediately after resection, and next 24, 48 and 72 hours after immersing in 10% buffered formalin.

Results: The contraction continued through the day 3, the mean contractility after one day was about 27%, after two days was 33% and after three days was 38%.

Conclusion: This study shows how the proximal esophageal margin can vary by the time, after immersing in 10% buffered formalin and should be considered in every settings and reporting documents by pathologists.

Keywords

Esophageal cancer

Marginal safety

Contractility

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