A Systematic Review of the Effects of Diffuse Optical Imaging in Breast Diseases

Ali Akbari Sari; M  Mobinizadeh; M Azadbakht

International Journal of Cancer Management

The Official Journal of Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences

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Abstract
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A Systematic Review of the Effects of Diffuse Optical Imaging in Breast Diseases

Author(s):

Ali Akbari Sari^1,*,

M Mobinizadeh²,

M Azadbakht³

1Dept. of Health Management and Economics, Tehran University of Medical Sciences, Tehran, Iran

2Dept. of Health Service Management, Science and Research Branch, Islamic Azad University, Tehran, Iran

3Dept. of Economics, University of Applied Science and Technology, Kohdasht Branch, Lorestan, Iran

International Journal of Cancer Management:Vol. 6, issue 1; e80385

Published online:Mar 30, 2013

Article type:Review Article

Received:Sep 30, 2012

Accepted:Dec 25, 2012

How to Cite:Ali Akbari SariM MobinizadehM AzadbakhtA Systematic Review of the Effects of Diffuse Optical Imaging in Breast Diseases.Int J Cancer Manag.6(1):e80385.

Abstract

Background: Optical mammography is a new diagnostic method that uses Nearinfrared for detection of functional abnormalities and shows tissue activities by measuring absorption and scattering of Near-infrared light. This study aims to evaluate the safety and effectiveness of this technology.

Methods: Cochrane Library (Issue 10, 2012) and Medline (Nov 2012) were searched using free text and Mesh. Studies that compared optical mammography with other diagnostic methods and used outcomes such as sensitivity, specificity and safety were included.

Results: Twelve studies were included in this review. A multicenter RCT showed that among 875 biopsied lesions, suspicion index led to 97% sensitivity, 14% specificity, 95% negative predictive value and 24% positive predictive value. In terms of oxygenation index, the included studies found that the process should be used with various wavelengths compared to single wavelength technique (690, 750, 788, 856 nm or 683, 912, 975nm). In terms of sensitivity and specificity, Diffuse Optical Tomography Computer Aided Detection is capable of distinguishing healthy tissues from malignant ones with 89% sensitivity and 94% specificity. Also, this technology could show increased blood flow around the tumor tissue compared to the healthy tissue effectively. Included studies did not report any information about the effects of technology on changing the treatment process or the final health outcomes.

Conclusion: Optical mammography is a safe, noninvasive, non-ionized diagnostic technology that can be used as a diagnostic supplement alongside conventional mammography for differentiating benign and malignant tumors. Women with higher breast density should be screened at younger ages and with more persistence than those who have lower densities.

Keywords

Optical mammography

Diffuse optical imaging

Near-infrared spectroscopy

Breast cancer

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