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A Systematic Review of the Effects of Diffuse Optical Imaging in Breast Diseases


avatar Ali Akbari Sari 1 , * , avatar M Mobinizadeh 2 , avatar M Azadbakht 3

1 Dept. of Health Management and Economics, Tehran University of Medical Sciences, Tehran, Iran

2 Dept. of Health Service Management, Science and Research Branch, Islamic Azad University, Tehran, Iran

3 Dept. of Economics, University of Applied Science and Technology, Kohdasht Branch, Lorestan, Iran

How to Cite: Akbari Sari A, Mobinizadeh M, Azadbakht M. A Systematic Review of the Effects of Diffuse Optical Imaging in Breast Diseases. Int J Cancer Manag. 2013;6(1):e80385.


International Journal of Cancer Management: 6 (1); e80385
Published Online: March 30, 2013
Article Type: Review Article
Received: September 30, 2012
Accepted: December 25, 2012


Background: Optical mammography is a new diagnostic method that uses Nearinfrared for detection of functional abnormalities and shows tissue activities by measuring absorption and scattering of Near-infrared light. This study aims to evaluate the safety and effectiveness of this technology.
Methods: Cochrane Library (Issue 10, 2012) and Medline (Nov 2012) were searched using free text and Mesh. Studies that compared optical mammography with other diagnostic methods and used outcomes such as sensitivity, specificity and safety were included.
Results: Twelve studies were included in this review. A multicenter RCT showed that among 875 biopsied lesions, suspicion index led to 97% sensitivity, 14% specificity, 95% negative predictive value and 24% positive predictive value. In terms of oxygenation index, the included studies found that the process should be used with various wavelengths compared to single wavelength technique (690, 750, 788, 856 nm or 683, 912, 975nm). In terms of sensitivity and specificity, Diffuse Optical Tomography Computer Aided Detection is capable of distinguishing healthy tissues from malignant ones with 89% sensitivity and 94% specificity. Also, this technology could show increased blood flow around the tumor tissue compared to the healthy tissue effectively. Included studies did not report any information about the effects of technology on changing the treatment process or the final health outcomes.
Conclusion: Optical mammography is a safe, noninvasive, non-ionized diagnostic technology that can be used as a diagnostic supplement alongside conventional mammography for differentiating benign and malignant tumors. Women with higher breast density should be screened at younger ages and with more persistence than those who have lower densities.


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