International Journal of Cancer Management:
Vol.6, issue 2; e80411
published online:
June
30,
2013
article type:
Review Article
received:
February
11,
2013
accepted:
April
09,
2013
Could Cancer Initiate From Bone Marrow Progenitors?
authors:
Hmed Ben Nasr
1
, *
,
Serria Turky Hammami
1
,
Khaled Zeghal
1
Dept. of Pharmacology, Medicine Faculty, Sfax University, Rue Magida Boulila, Sfax, Tunisia
how to cite:
Ben Nasr
H , Turky Hammami
S, Zeghal
K. Could Cancer Initiate From Bone Marrow Progenitors?. Int J Cancer Manag. 2013;6(2):e80411.
Abstract
Background: Defining cancer stem cells and their origins is of much controversy, and constitutes a challenged knockout for cell targeting- anticancer drugs. Herein, we put forward a hypothetic model for cancer stem cells initiation from bone marrow stem cells. These later, will differentiate into an ancestral progenitor that activates a memorial program – the black box cassette- that is responsible of abnormal neo-organogenesis in the form of tumors and metastases. To approve this model, we assume that characterizing and investigating the most primitive forms of the bone marrow progenitors is required; both inside their niche and in circulation of cancer patients.