Malignant giant cell tumor of soft parts in lumbosacral region

Farzaneh  Jadali; A Almasi; A Gharib

International Journal of Cancer Management

The Official Journal of Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences

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Malignant giant cell tumor of soft parts in lumbosacral region

Author(s):

Farzaneh Jadali ^1,*,

A Almasi²,

A Gharib³

1Associate Professor, PIRC (Pediatric Infection Research Centre), Shahid Beheshti Medical University (MC), Mofid Hospital, Iran

2Pathologist, Iranian Blood Transfusion Organization (IBTO), Iran

3Assistant Professor, PIRC (Pediatric Infection Research Centre) Shahid Beheshti Medical University (MC), Mofid Hospital, Iran

International Journal of Cancer Management:Vol. 1, issue 2; e80430

Published online:Apr 30, 2008

Article type:Case Report

Received:Apr 30, 2008

Accepted:Apr 30, 2008

How to Cite:Farzaneh Jadali A AlmasiA GharibMalignant giant cell tumor of soft parts in lumbosacral region.Int J Cancer Manag.1(2):e80430.

Abstract

Background: Giant cell tumor of soft parts is a rare neoplasm that mainly affects adulst and the elderly and is usually located in the extremities. Here we report a child with giant cell tumor of soft tissue, which is a very rare condition in childhood.

Clinical presentation: A 5 year old girl presented with a 5 month history of left lower extremity pain. She had developed paraplegia before admission. On examination, mild left lumbosacral swelling and tenderness was found. Abdominal and pelvic CT-Scan revealed an expansile lytic lesion of the left side of sacrum with significant soft tissue component extending toward the left iliac bone. Lumbar MRI revealed a space occupying lesion originating from posterior L5 elements, projecting toward the L1.

Intervention: The patient underwent surgery. A firm epidural hemorrhagic tumor of L5, S1, and S2 with no spinal cord involvement was found. Partial tumor resection (measuring 3*1*0.5 cm in maximal diameter) and laminectomy was done.

Conclusion: Primary giant cell tumors of soft tissue are distinctive, rare neoplasms that exhibit a wide clinicopathologic spectrum similar to osseous GCTs and need to be differentiated from other giant cell rich soft tissue tumors. Recognition of this tumor is important due to its behavior as a low grade malignancy, but this cannot be predicted and metastasis does occur rarely.

Keywords

Giant cell tumor of soft tissue (GCT-ST)

large cell sarcoma of tendon sheath

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