Plasma Selenium Concentration and Glutathione Peroxidase Activity in Breast Cancer Patients Before and After Chemotherapy

Masoumeh  Moradi; MH Eftekhari; A Talei

International Journal of Cancer Management

The Official Journal of Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences

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Plasma Selenium Concentration and Glutathione Peroxidase Activity in Breast Cancer Patients Before and After Chemotherapy

Author(s):

Masoumeh Moradi ^1,*,

MH Eftekhari¹,

A Talei²

1Department of Nutrition, School of Health, Medical Sciences/ University of Shiraz, Iran

2Professor of surgery, Shiraz University of Medical Sciences, Iran

International Journal of Cancer Management:Vol. 1, issue 3; e80464

Published online:Sep 30, 2008

Article type:Research Article

Received:Sep 30, 2008

Accepted:Sep 30, 2008

How to Cite:Masoumeh Moradi MH EftekhariA TaleiPlasma Selenium Concentration and Glutathione Peroxidase Activity in Breast Cancer Patients Before and After Chemotherapy.Int J Cancer Manag.1(3):e80464.

Abstract

Background: The chemotherapeutic agents used for treatment of breast cancer are all shown to increase free oxygen radicals and generation of reactive oxygen species. The aim of this study was to evaluate effect of chemotherapy on plasma selenium (Se) concentration and glutathione peroxidase (GPX) activity in breast cancer patients.

Materials and Methods: Seventeen women in stage II and III breast cancer were randomly selected from their population. Plasma Se was measured with Graphite furnace atomic absorption spectroscopy and GPX activity in erythrocyte by using spectrophotometric at baseline (before chemotherapy) and after chemotherapy. normally distributed data was expressed as mean ± standard deviation. Statistical analysis was performed using Paired T-Test. Results: plasma Se concentration before and after chemotherapy was in normal range and no statistically difference was observed (156.23±25 µg/L vs. 145.23±23 µg/L respectively). After chemotherapy, there was a significant (p<0.05) higher erythrocyte GPX activity, as compared to initial activity at baseline. (22.28±4 U/grHb vs. 26.39± 4 U/grHb respectively).

Conclusion: This study indicates that sufficient Se could increase GPX activity with have a protective effect against oxidative damages.

Keywords

breast cancer

chemotherapy

glutathione peroxidase

selenium

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