Breast Cancer Biomarker Discovery: Proteomics and Genomics Approaches

Akram Safaei; Mostafa Rezaei‐Tavirani; Sara Sobhi; MohammadEsmaeil Akbari

International Journal of Cancer Management

The Official Journal of Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences

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Breast Cancer Biomarker Discovery: Proteomics and Genomics Approaches

Author(s):

Akram Safaei¹,

Mostafa Rezaei‐Tavirani¹,

Sara Sobhi²,

MohammadEsmaeil Akbari^2,*

1Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

International Journal of Cancer Management:Vol. 6, issue Supplement; e80465

Published online:Dec 30, 2013

Article type:Review Article

Received:Sep 27, 2012

Accepted:Nov 19, 2012

How to Cite:Akram SafaeiMostafa Rezaei‐TaviraniSara SobhiMohammadEsmaeil AkbariBreast Cancer Biomarker Discovery: Proteomics and Genomics Approaches.Int J Cancer Manag.6(Supplement):e80465.

Abstract

Breast cancer is one of the major health problems of the Eastern world. Regardless of the survival rate improvement with progression in screening and adjuvant systemic therapies, still one – third of the patients with primary breast cancer have recurrence of micro metastasis after 10 years. It is important to discover a reliable biomarker for detection of breast cancer. The underlying molecular mechanism of the disease needs to be better understood. Allied to genomics, proteomics technologies promise to be valuable for identifying new markers that improve screening, early diagnosis, prognosis and prediction of therapeutic response or toxicity, as well as the identification of new therapeutic targets. In this review, we present proteomic and genomic sciences have been used for differential analysis of breast cancer to find molecular changes of cancer for detection candidate biomarkers.

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