Aqueous Extract of Lavender Angustifolia Inhibits Lymphocytes Proliferation of Hodgkin's Lymphoma Patients


avatar Sona Dalilan 1 , avatar Mostafa Rezaei Tavirani 2 , * , avatar Mohammad Nabiuni 3 , avatar Saeed Heidari-Keshel 2 , avatar Mona Zamanian Azodi 2 , avatar Hakimeh Zali 2

Science and Research Branch, Islamic Azad University, Tehran, Iran
Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Dept. of Biology, Faculty of Basic Sciences, Tarbiat Moallem University, Tehran, Iran

how to cite: Dalilan S, Rezaei Tavirani M , Nabiuni M, Heidari-Keshel S, Zamanian Azodi M, et al. Aqueous Extract of Lavender Angustifolia Inhibits Lymphocytes Proliferation of Hodgkin's Lymphoma Patients. Int J Cancer Manag. 2013;6(4):e80471. 


Background: There are several types of cancer, which cause millions of deaths worldwide every year. Many studies have confirmed that plants are adequate natural sources to be examined as anti-cancer drugs with fewer side effects than chemotherapy and radiotherapy. In this study the anti-cancer properties of Lavender aqueous extract on lymphocytes derived from patients with Hodgkin's lymphoma has been studied.
Methods: In order to determine the cytotoxic effects of the extract on lymphocytes of patients in stages III and IV of Hodgkin's lymphoma and two different cell lines in the presence of different concentrations of aqueous extract of Lavender, MTT colorimetric assay and flow cytometry analysis were used.
Results: Findings indicated that Lavender inhibited cell proliferation in both lymphocytes and cell lines with different effects. The effective concentration of Lavender that decreased viability of Hodgkin's lymphoma cells below Lethal Concentration 50 (LC50) value was 100 µg/ml and this was half of the therapeutic dose. In addition, apoptosis was the main mechanism the Hodgkin's lymphoma cell encountered when exposed to the aqueous extract of Lavender.
Conclusion: This experiment proposes that aqueous Lavender extract can be regarded as a potential anti-cancer agent in future studies.


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