Association between Genetic Polymorphism of Methylenetetrahydrofolate Reductase with Non Familial Colorectal Cancer in Iranian Population

Mahdi Montazer Haghighi; R Radpour; M Vahedi; SR Mohebbi; F Khatami; F Derakhshan; H Atarian; MR Zali

International Journal of Cancer Management

The Official Journal of Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences

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Abstract
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Association between Genetic Polymorphism of Methylenetetrahydrofolate Reductase with Non Familial Colorectal Cancer in Iranian Population

Author(s):

Mahdi Montazer Haghighi^1,*,

R Radpour²,

M Vahedi³,

SR Mohebbi³,

F Khatami³,

F Derakhshan³,

H Atarian⁴,

MR Zali³

1Research Center for Gastroenterology and Liver Diseases, Shahid Beheshti University (MC), Taleghani Hospital; Department of Genetics, Faculty of Science, Islamic Azad University, East of Tehran branch, Iran

2Research Center for Gastroenterology and Liver Diseases, Shahid Beheshti University (MC), Taleghani Hospital, Tehran, Iran; Laborenatal Medicine, Department of Obstetrics Gynecology and Oncology, University oatory for Prf Basel, Switzerland

3Research Center for Gastroenterology and Liver Diseases, Shahid Beheshti University (MC), Taleghani Hospital, Iran

4Department of Oncology, , Shahid Beheshti University (MC), Taleghani Hospital, Iran

International Journal of Cancer Management:Vol. 1, issue 3; e80489

Published online:Sep 30, 2008

Article type:Research Article

Received:Sep 30, 2008

Accepted:Sep 30, 2008

How to Cite:Mahdi Montazer HaghighiR RadpourM VahediSR MohebbiF KhatamiF DerakhshanH AtarianMR Zaliet al.Association between Genetic Polymorphism of Methylenetetrahydrofolate Reductase with Non Familial Colorectal Cancer in Iranian Population.Int J Cancer Manag.1(3):e80489.

Abstract

Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme regulating folate metabolism, which affects DNA methylation and synthesis. One of the most important polymorphisms identified in the MTHFR gene is C677T. MTHFR activity is lowered in individuals with 677TT genotype. Using pyrosequencing, we analyzed the MTHFR genotypes in 118 colorectal cancer patients and 189 normal matched controls. Whereas the CC, CT and TT genotypes of MTHFR among the colorectal cancer patients were 51.7%, 28.0 % and 20.3% respectively, we were able to find 47.1% of 677CC, 27.0% of 677CT and 25.9% of 677TT in normal controls. An inverse association was observed between the risk of colorectal cancer and TT genotype with the odds ratios (OR) of 1, 0.94 and 0.71 for CC, CT, and TT genotypes, respectively. This association was similar in both sexes, but in patients with high levels of folate intake. Our study corroborates previous findings of an inverse association between MTHFR 677TT genotype and colorectal cancer, especially at high levels of folate.

Keywords

non familial colorectal cancer

methylenetetrahydrofolate reductase

pyrosequencing

polymorphism

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