Diagnosis of Post-Radiotherapy Local Failures in Nasopharyngeal Carcinoma: A Prospective Institutional Study

Puneet Bagri; Mukesh Singhal; Daleep Singh; Akhil Kapoor; Shankar Lal Jakhar; Neeti Sharma; Surender Beniwal; Harvindra Kumar; Ajay Sharma; Megh Bardia

International Journal of Cancer Management

The Official Journal of Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences

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Diagnosis of Post-Radiotherapy Local Failures in Nasopharyngeal Carcinoma: A Prospective Institutional Study

Author(s):

Puneet Bagri^1,*,

Mukesh Singhal¹,

Daleep Singh¹,

Akhil Kapoor¹,

Shankar Lal Jakhar¹,

Neeti Sharma¹,

Surender Beniwal²,

Harvindra Kumar¹,

Ajay Sharma¹,

Megh Bardia¹

1Dept. of Radiation Oncology, Acharya Tulsi Regional Cancer Treatment & Research Institute, Bikaner-334003, Rajasthan, India

2Medical Oncology section, Acharya Tulsi Regional Cancer Treatment & Research Institute, Bikaner-334003, Rajasthan, India

International Journal of Cancer Management:Vol. 7, issue 1; e80507

Published online:Mar 31, 2014

Article type:Research Article

Received:Oct 26, 2013

Accepted:Dec 02, 2013

How to Cite:Puneet BagriMukesh SinghalDaleep SinghAkhil KapoorShankar Lal JakharNeeti SharmaSurender BeniwalHarvindra KumarAjay SharmaMegh Bardiaet al.Diagnosis of Post-Radiotherapy Local Failures in Nasopharyngeal Carcinoma: A Prospective Institutional Study.Int J Cancer Manag.2014;7(1):e80507.

Abstract

Background: This prospective study was conducted to evaluate and compare the efficacies of nasopharyngoscopy and CT scan in the diagnosis of local failure of external beam radiotherapy (EBRT) for nasopharyngeal carcinoma. Methods: Total 52 patients of histopathologically proven nasopharyngeal carcinoma treated with external beam radiotherapy (EBRT), were included in this study. For every patient computed tomography (CT), nasopharyngoscopy and nasopharyngeal biopsies were performed 3 months after completion of EBRT.

Results: Three months after completion of EBRT, 9 patients (17.3%) had evident disease on histological examination of biopsies. Nasopharyngoscopy showed 77.78% sensitivity, 93.03% specificity, 70% positive predictive value and 95.24% negative predictive value in diagnosing the residual/recurrence of tumor. There was statistically significant agreement between the endoscopic findings and the histological findings (Kappa reliability coefficient=0.562, p0.05). Conclusion: Nasopharyngoscopy should be considered the primary follow-up tool after radiotherapy of nasopharyngeal carcinoma. CT scan should be reserved for patients with histological or any symptomatic indications. Routine postnasal biopsies are not required.

Keywords

Nasopharyngeal carcinoma

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