Granzyme H Serum Levels Variations with Both Reproductive Hormone Receptors, and Related Hormone Receptors in Breast Cancer Patients

Behnoosh Tahbaz-lahaf; MohammadEsmaeil Akbari; Houshang Amir-Rassouli; Ali Rahimipour; Eznollah Azargashb; Nahid Nafissi; Farida Jahani

International Journal of Cancer Management

The Official Journal of Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences

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Abstract
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Granzyme H Serum Levels Variations with Both Reproductive Hormone Receptors, and Related Hormone Receptors in Breast Cancer Patients

Author(s):

Behnoosh Tahbaz-lahaf¹,

MohammadEsmaeil Akbari^2,*,

Houshang Amir-Rassouli¹,

Ali Rahimipour¹,

Eznollah Azargashb²,

Nahid Nafissi²,

Farida Jahani²

1Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

International Journal of Cancer Management:Vol. 7, issue 1; e80509

Published online:Mar 31, 2014

Article type:Research Article

Received:Nov 02, 2013

Accepted:Dec 21, 2013

How to Cite:Behnoosh Tahbaz-lahafMohammadEsmaeil AkbariHoushang Amir-RassouliAli RahimipourEznollah AzargashbNahid NafissiFarida Jahaniet al.Granzyme H Serum Levels Variations with Both Reproductive Hormone Receptors, and Related Hormone Receptors in Breast Cancer Patients.Int J Cancer Manag.2014;7(1):e80509.

Abstract

Background: Breast Cancer (BC) is the most common cancer in Iranian women, meanwhile the Iranian patients are relatively young. Granzyme H (GZMH) is a functional cytotoxic serine protease of NK cell granules, which expands the cell death-inducing repertoire of innate immune system. GZMH is constitutively and highly expressed in human NK cells, in order to possess chymotrypsin-like (chymase) enzymatic activity. The purpose of this study was to determine GZMH level, in BC and healthy women.

Methods: 30 breast cancer patients, and 30 control women in premenopausal status, have participated in this study. GZMH, Estrogen levels, and ER, PR have been measured in cancer and healthy women subsequently, as using ELISA, Radioimmunoassay, and Immunohistochemistry methods.

Results: Mean GZMH value was lower in BC than healthy women (p<0.0001).

Conclusion: Our study has implicated existence of suppressor or problem for producing of GZMH in patients group and levels of estrogen couldn’t effect on making positive ER, PR.

Keywords

Breast Cancer

Estrogen

Granzyme H

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