Antiphospholipid Antibodies in Neoplastic Patients

M R  Mortazavizadeh; R Sadeghmanesh

International Journal of Cancer Management

The Official Journal of Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences

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Antiphospholipid Antibodies in Neoplastic Patients

Author(s):

M R Mortazavizadeh^1,*,

R Sadeghmanesh²

1Assistant Professor of Hematology and Oncology Department, Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

2General Practitioner, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

International Journal of Cancer Management:Vol. 2, issue 2; e80526

Published online:Jun 30, 2009

Article type:Research Article

Received:Jun 30, 2009

Accepted:Jun 30, 2009

How to Cite: M R MortazavizadehR SadeghmaneshAntiphospholipid Antibodies in Neoplastic Patients.Int J Cancer Manag.2(2):e80526.

Abstract

Background: Anti-phospholipid syndrome (APS) is an autoimmune systemic disease characterized by the persistent presence of anti-phospholipid antibodies (APA) and the occurrence of thrombotic events. Nowadays, the association between specific antibodies for anionic phospholipids with thrombotic events and other main clinical manifestations is well-recognized as "antiphospholipid syndrome". The present study was done to evaluate the frequency of antiphospholipid antibodies in neoplastic patients.

Material and methods: One hundred and eighty patients were included in this cross sectional study. Their suspected neoplasm disorders were confirmed by pathology or flowcytometry. History taking and clinical examination were done for patients to detect all symptomatic clinical thrombotic events. Antiphospholipid antibodies were tested for all patients.

Results: The study was concluded with 156 study samples. Thirty three patients (21.2%) had antiphospholipid antibodies. There was no significant difference on antiphospholipid antibodies frequency between two genders. APA frequency showed no significant difference between solid or non-solid tumors. The rate of thrombosis was significantly higher in neoplastic patients with antiphospholipid antibodies.

Conclusion: Frequency of antiphospholipid antibodies was significantly higher in neoplastic patients. Antiphospholipid antibodies were one of the multifactorial accelerating factors for thrombotic events in neoplastic patients.

Keywords

antiphospholipid antibody

thrombotic events

neoplastic patient

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