Geographic Heterogeneity of Cytogenetic Characteristics of Acute Myeloid Leukemia in the early detection: A Comparative Study of Iranian and Indian adult Patients

Abolfazl Movafagh; A Hajifathali; F Isfahani; H Attarian; M Ghadiani; H Rezvani; MH Heidari; R Miri; M Haji Seyed Javadi

International Journal of Cancer Management

The Official Journal of Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences

Geographic Heterogeneity of Cytogenetic Characteristics of Acute Myeloid Leukemia in the early detection: A Comparative Study of Iranian and Indian adult Patients

Author(s):

Abolfazl Movafagh^1,*,

A Hajifathali²,

F Isfahani²,

H Attarian ²,

M Ghadiani²,

H Rezvani²,

MH Heidari³,

R Miri⁴,

M Haji Seyed Javadi⁵

1Associate Professor of Genetics, Shahid Beheshti University (MC), Tehran, Iran

2Associate Professor of Oncology, Shahid Beheshti University (MC), Tehran, Iran

3Associate Professor of Anatomy, Shahid Beheshti University (MC), Tehran, Iran

4Department of Physiology, Shahid Beheshti University(MC), Tehran, Iran

5Research Assistant, Iran

International Journal of Cancer Management:Vol. 2, issue 2; e80536

Published online:Jun 30, 2009

Article type:Research Article

Received:Jun 30, 2009

Accepted:Jun 30, 2009

How to Cite:Abolfazl MovafaghA HajifathaliF IsfahaniH Attarian M GhadianiH RezvaniMH HeidariR MiriM Haji Seyed Javadiet al.Geographic Heterogeneity of Cytogenetic Characteristics of Acute Myeloid Leukemia in the early detection: A Comparative Study of Iranian and Indian adult Patients.Int J Cancer Manag.2(2):e80536.

Abstract

Background: Acute Meyloid Leukemia (AML) in adults is known to be a heterogeneous disease with diverse chromosome abnormalities. Some of these chromosome abnormalities are found with a high incidence in populations from specific geographical areas and ethnic societies. Therefore, we studied the cytogenetic features of AML cases in contrasting societies of Iran and India.

Methods: Cytogenetic investigation was performed in various subtypes of AML with unstimulated short-term culture and High Resolution Cell Synchronization with some modification.

Results: Cytogenetically, Iranian M3 displayed a higher frequency of t(15;17) than Indian M3 (33.8% vs 19.3%) followed by M2 [t(8;21) (27.7% vs 16.2%)] and M1 [t(9;22) (16.0% vs 11.3%)]; whereas, inv(16)11q23 and numerical chromosomal aberrations in chromosome 5,7,8 occurred more frequently in Indian than Iranian.

Conclusion: These findings represented different cytogenetic characteristics of t(15;17) between the two populations. This is the first systematic cytogenetic study of an ethnic Iranian population. Extensive biological studies of AML in Iran and India and various countries to be needed to clarify the role of genetic as well as geographic heterogeneity in the pathogenesis of AML.

Keywords

acute myeloid leukemia

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