Primary Non-Hodgkin Lymphoma of the Stomach: Clinicopathological Characteristics and Prognostic Factors in Iranian Patients

Sare Hosseini; Parvaneh  Dehghan

International Journal of Cancer Management

The Official Journal of Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences

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Primary Non-Hodgkin Lymphoma of the Stomach: Clinicopathological Characteristics and Prognostic Factors in Iranian Patients

Author(s):

Sare Hosseini¹,

Parvaneh Dehghan^2,*

1Solid Tumor Treatment Research Center, Omid Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

2Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran

International Journal of Cancer Management:Vol. 7, issue 4; e80561

Published online:Dec 31, 2014

Article type:Research Article

Received:Jun 14, 2014

Accepted:Sep 03, 2014

How to Cite:Sare HosseiniParvaneh DehghanPrimary Non-Hodgkin Lymphoma of the Stomach: Clinicopathological Characteristics and Prognostic Factors in Iranian Patients.Int J Cancer Manag.7(4):e80561.

Abstract

Background: Primary Gastric Lymphoma (PGL) is an uncommon malignancy with various histological subtypes and treatment outcomes. The aim of this study was to investigate the potential prognostic factors and clinicopathological characteristics of Iranian patients with PGL.

Methods: The clinicopathological characteristics of 60 patients with PGL were retrospectively reviewed from 2001 to 2012. The patients underwent various combinations of chemotherapy, radiotherapy, and surgery. We evaluated multiple potential prognostic factors and their associations with patient survival rate.

Results: According to the results, Diffuse Large B-cell Lymphoma (DLBCL) and Mucosa-Associated Lymphoid Tissue (MALT) were two predominant histological subtypes. The majority of cases were diagnosed with stage I tumor in the distal part of the stomach. The 5-year disease-free survival (DFS) and overall survival (OS) rates were 60% and 70%, respectively. It was revealed that poor World Health Organization (WHO) performance status, presence of B symptoms, and International Prognostic Index (IPI) score≥3 were significantly associated with decreased patient survival.

Conclusion: Most of the patients with PGL in early stage have a favorable prognosis.

Keywords

Non-Hodgkin lymphoma

stomach

prognostic factor

overall survival rate

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