The PrognosticRole of Tumor Marker CA-125 in B-Cell

authors:

avatar Bahram Memar 1 , avatar Seyed Amir Aledavood 2 , * , avatar Soodabeh Shahidsales 2 , avatar Mitr Ahadi 3 , avatar Mahdi Farzadnia 4 , avatar Hamid Reza Raziee 2 , avatar Sedighe Noori 5 , avatar Naser Tayebi-Meybodi 4 , avatar Sakineh Amouian 4 , avatar Samira Mohtashami 2

Surgical Oncology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Cancer Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Dept. of Internal, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Dept. of Pathology, Imam Reza Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Medical Student, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

how to cite: Memar B, Aledavood S A, Shahidsales S, Ahadi M, Farzadnia M, et al. The PrognosticRole of Tumor Marker CA-125 in B-Cell. Int J Cancer Manag. 2015;8(1):e80580.

Abstract

Background: B-cell non-Hodgkin’s lymphoma (NHL) is a common malignancy of lymphoid tissues. Different types of NHL show various behaviors, prognoses, and responses to treatment. Evaluation of disease activity in NHL can be helpful in managing and even increasing the patient’s survey.
Methods and Results: In total, 121 patients (76 males and 45 females), and their age range were 18-53 years, were evaluated in this study. The mean level of serum carbohydrate antigen 125 (CA-125) was 89.3±18.5 u/ml, ranging from 27 to 135 u/ml. There were significant differences in International Prognostic Index (IPI) score (p=0.002), stage of the disease (p=0.006), mortality rate (p=0.02), and relapse rate (p=0.04) between patients with serum CA-125 level 35 u/ml.
Conclusion: CA-125 seems to be a useful and reliable tumor marker for monitoring a patient with NHL. It might be the time to consider CA-125 in staging, prognostic scoring, or decision making about NHL treatment.

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