Detection of E-6 Antigen (Human Papilloma Virus-16) and H11B2C2 Antigen (Habp) in Cervical Cancer Tissues


avatar Siddaiah Manjunath 1 , * , avatar D Sudhakar 1 , avatar B Fekry 1 , avatar KK Mortha 1

Cancer Biology Lab, Department of Biochemistry, University of Mysore, Mysore, India

how to cite: Manjunath S, Sudhakar D, Fekry B, Mortha K. Detection of E-6 Antigen (Human Papilloma Virus-16) and H11B2C2 Antigen (Habp) in Cervical Cancer Tissues. Int J Cancer Manag. 2010;3(3):e80704.


Background: Cervical cancer is one of the most common types of women’s reproductive cancers. A major risk factor for cervical cancer is exposure to a group of common sexually transmitted viruses called Human papillomavirus (HPV). The over expression of HPV 16 i.e., E6 antigen in the tumors of suspected cervical cancer tissues. however E-6 antigen has hyaluronan binding protein site.
Methods: The procedure carried out by using 15 benign and 50 different grades of cervical cancer tissue samples to study the expression of HPV 16 i.e., E6 antigen and H11 antigen(HABP) by biochemical method.
Results: The HPV 16 i.e., 18KD is expressing along with hyaluronic acid binding proteins 57KD and 92KD. This shows that E-6 antigen itself reacting with hyaluronic acid binding sites.
Conclusion: The H11 antigen (HABP) reacted with anti E-6 protein indicating hyaluronic acid binding protein 57KD and 92 KD is reacting with anti E6 antibody. These results showed a partial homology between E6 and H11 antigen (HABP). Thus the homology between the two proteins in tumor cells is an important parameter and a clinical diagnostic marker for progressive human tumors.


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