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International Journal of Cancer Management
The Official Journal of Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences
e-ISSN 2538-497X
p-ISSN 2538-4422
Detection of E-6 Antigen (Human Papilloma Virus-16) and H11B2C2 Antigen (Habp) in Cervical Cancer Tissues
Authors
1Cancer Biology Lab, Department of Biochemistry, University of Mysore, Mysore, India
*Corresponding Author: Corresponding author: Siddaiah Manjunath, Cancer Biology Lab, Department of Biochemistry, University of Mysore, Mysore, India, Tel: +91-9611980269, E-mail: Email: [email protected]
Published online:Sep 30, 2010
Article type:Research Article
Received:May 03, 2010
Accepted:Jul 01, 2010
How to Cite:Manjunath S, Sudhakar D, Fekry B, Mortha K. Detection of E-6 Antigen (Human Papilloma Virus-16) and H11B2C2 Antigen (Habp) in Cervical Cancer Tissues. Int J Cancer Manag. 2010;3(3):e80704. doi:
Abstract
Background: Cervical cancer is one of the most common types of women’s reproductive cancers. A major risk factor for cervical cancer is exposure to a group of common sexually transmitted viruses called Human papillomavirus (HPV). The over expression of HPV 16 i.e., E6 antigen in the tumors of suspected cervical cancer tissues. however E-6 antigen has hyaluronan binding protein site.
Methods: The procedure carried out by using 15 benign and 50 different grades of cervical cancer tissue samples to study the expression of HPV 16 i.e., E6 antigen and H11 antigen(HABP) by biochemical method.
Results: The HPV 16 i.e., 18KD is expressing along with hyaluronic acid binding proteins 57KD and 92KD. This shows that E-6 antigen itself reacting with hyaluronic acid binding sites.
Conclusion: The H11 antigen (HABP) reacted with anti E-6 protein indicating hyaluronic acid binding protein 57KD and 92 KD is reacting with anti E6 antibody. These results showed a partial homology between E6 and H11 antigen (HABP). Thus the homology between the two proteins in tumor cells is an important parameter and a clinical diagnostic marker for progressive human tumors.
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© 2010, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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