Epidermal Growth Factor Receptor Gene in Prostate Cancer after Radical Prostatectomy

Bahram Mofid; MR Jalali Nadoushan; A Rakhsha; HR  Mirzaei; L  Zeinali

International Journal of Cancer Management

The Official Journal of Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences

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Epidermal Growth Factor Receptor Gene in Prostate Cancer after Radical Prostatectomy

Author(s):

Bahram Mofid^1,*,

MR Jalali Nadoushan²,

A Rakhsha¹,

HR Mirzaei¹,

L Zeinali¹

1Dep. of Oncology, Shohada Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2Dep. of Pathology, Shahed University, Tehran, Iran

International Journal of Cancer Management:Vol. 3, issue 4; e80713

Published online:Dec 31, 2010

Article type:Research Article

Received:Jul 06, 2010

Accepted:Sep 20, 2010

How to Cite:Bahram MofidMR Jalali NadoushanA RakhshaHR MirzaeiL ZeinaliEpidermal Growth Factor Receptor Gene in Prostate Cancer after Radical Prostatectomy.Int J Cancer Manag.3(4):e80713.

Abstract

Background: The aim of this study was to evaluate over expression of epidermal growth factor receptor (EGFR) gene in localized prostate cancers and determine its relation with clinical and pathological factors affecting the progression of the disease.

Methods: In the tissue samples of the patients with prostate cancer undergoing radical prostatectomy, EGFR expression was evaluated by immunohistochemistry technique. Those with scores 2 and 3 were considered to be positive for the expression. The relation between gene expression and grade was evaluated by chi-square test. Results: Of 100 tissue samples evaluated, 80 and 20 had Gleason score (GS) < 7 and ≥ 7, respectively. Also, 68 and 32 had PSA level ≤ 10 and >10, respectively. A total of 59 samples were positive for EGFR expression, of whom, 46 had GS < 7 and 13 had GS > 7 (P-value = 0.39). Forty patients had PSA < 10 and 19 had PSA > 10 (P-value = 0.5). Conclusion: Fifty-nine percent of the patients with localized prostate cancer undergoing radical prostatectomy were EGFR positive. No significant relation was found between EGFR and grading (GS) or PSA.

Keywords

Epidermal growth factor receptor

Gene expression

Prostate cancer

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