Recurrence and Survival Effect in Breast Conserving Surgery: What are the Predictive and/or Prognostic Factors?

ME Akbari; M Mozaffar; A Heidari; H Zirakzadeh; Atieh Akbari; M Akbari; F Hosseinizadegan Shirazi

International Journal of Cancer Management

The Official Journal of Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences

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Abstract
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Recurrence and Survival Effect in Breast Conserving Surgery: What are the Predictive and/or Prognostic Factors?

Author(s):

ME Akbari¹,

M Mozaffar¹,

A Heidari¹,

H Zirakzadeh¹,

Atieh Akbari^1,*,

M Akbari¹,

F Hosseinizadegan Shirazi¹

1Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

International Journal of Cancer Management:Vol. 4, issue 2; e80729

Published online:Jun 30, 2011

Article type:Research Article

Received:Jan 09, 2011

Accepted:Mar 25, 2011

How to Cite:Akbari M, Mozaffar M, Heidari A, Zirakzadeh H, Akbari A, et al. Recurrence and Survival Effect in Breast Conserving Surgery: What are the Predictive and/or Prognostic Factors?.Int J Cancer Manag.2011;4(2):e80729.

Abstract

Background: Breast conserving surgery (BCS) is a widely accepted form of operation in patients with early breast cancer. Recurrence remains one of the greatest concerns in breast conserving surgery. It can provoke serious anxiety in the patient and, when treated by mastectomy, negate the objective of conservation.

Methods: In this study we investigated the prognostic value of demographic, clinical and pathological factors and biological markers in breast cancer patients treated with BCS. This study was performed on 258 patients who underwent BCS from 2002 to 2010. All of the surgeries were performed by a single surgical team. Recurrence and its risk factors were evaluated.

Results: The mean age of the patients at the time of diagnosis was 50. The overall 10 year survival was 81%, 5 year survival was 88% and recurrence rate after surgery was 9%. Lymphovascular Invasion (LVI) was observed in 41 (16%) patients and in 11 (48%) patients with recurrence.

Conclusion: Our study confirmed that tumors with estrogen receptor negative and LVI had more recurrence rate but other demographic, clinical and pathological factors and biological markers (progesterone receptor, P53, HER-2) did not have any significant effect on recurrence. We recommend considering LVI and estrogen receptor assay as a prognostic factor in the patients treated with BCS.

Keywords

Breast cancer

Breast conserving surgery

Recurrence

Survival

Biological markers

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Search Relations

Author(s):

ME Akbari:[PubMed][Scholar]
M Mozaffar:[PubMed][Scholar]
A Heidari:[PubMed][Scholar]
H Zirakzadeh:[PubMed][Scholar]
Atieh Akbari:[PubMed][Scholar]
M Akbari:[PubMed][Scholar]
F Hosseinizadegan Shirazi:[PubMed][Scholar]