Human Papilloma Virus in Head and Neck Squamous Cell Cancer

I Asvadi Kermani; Sharareh  Seifi; R Dolatkhah; E Sakhinia; S Dastgiri; A Ebrahimi; A Lotfy; HA Esmaeili; G Mohammadi; M Naderpour; SH Hajalipour; A Asghari Haggi; M Nadri

International Journal of Cancer Management

The Official Journal of Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences

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Human Papilloma Virus in Head and Neck Squamous Cell Cancer

Author(s):

I Asvadi Kermani¹,

Sharareh Seifi^1,*,

R Dolatkhah¹,

E Sakhinia²,

S Dastgiri³,

A Ebrahimi¹,

A Lotfy⁴,

HA Esmaeili⁵,

G Mohammadi⁴,

M Naderpour⁴,

SH Hajalipour⁴,

A Asghari Haggi¹,

M Nadri¹

1Haematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

2Dept. of Biochemistry, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

3Dept. of Social Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

4Dept. of ENT, Tabriz University of Medical Sciences, Tabriz, Iran

5Dept. of Pathology, Tabriz University of Medical Sciences, Tabriz, Iran

International Journal of Cancer Management:Vol. 5, issue 1; e80792

Published online:Mar 31, 2012

Article type:Research Article

Received:Nov 02, 2011

Accepted:Dec 03, 2011

How to Cite:I Asvadi KermaniSharareh SeifiR DolatkhahE SakhiniaS DastgiriA EbrahimiA LotfyHA Esmaeili G MohammadiM NaderpourSH HajalipourA Asghari HaggiM Nadriet al.Human Papilloma Virus in Head and Neck Squamous Cell Cancer.Int J Cancer Manag.5(1):e80792.

Abstract

Background: Epidemiologic and molecular evidences have established a strong link between high risk types of Human Papilloma Virus and a subgroup of Head and Neck Squamous Cell Carcinomas (HNSCC). We evaluated the frequency of HPV positivity in HNSCC and its relationship to demographic and some risk factor variables in an open casecontrol study.

Methods: Fourteen recently diagnosed patients with squamous cell cancer of oropharynx, hypopharynx and larynx aged 18-50 years were examined from 2008-2010 in Tabriz, Iran. HPV DNA was extracted from paraffin-embedded blocks of each patient's sample for PCR evaluation. Saliva samples of 94 control cancer-free subjects were collected for DNA analysis. Multivariable logistic regression method was used to calculate odds ratio for case-control comparisons.

Results: High risk HPV was detected in 6(42.8%) patients, and 6(5.3%) control subjects which was statistically significant (p<0.0001). HPV-18 was the most frequent type both in the cases and controls. HPV-16 DNA was detected in two patients of the case group, but it was not detected in any of the controls. The relation between demographic and risk factor variables was not statistically significant.

Conclusion: HPV infection has a significant impact on HNSCC. Despite HPV-16 stronger impact, HPV-18 is more likely to cause malignant degeneration in such cancers amongst some communities. It is vital to introduce and conduct immunization schedules in health care systems to protect communities to some extent.

Keywords

Head and Neck Neoplasms

Squamous Cell Carcinoma

Human Papilloma Virus 16

Human Papilloma Virus 18

Sex

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