Survey on Childhood Solid Malignant Tumors in Cases Admitted to Mofid Pediatric Hospital From 1996-2010: a Single-Center Study

Farzaneh  Jadali; Hosein Aghayan Golkashani; Golareh Habibi; Mohsen Rouzrokh; Fatemeh Abdollah Gorji; Fahimeh Dini; Malihe Khodami; Yalda Nilipour; Ahmad Khaleghnejad Tabari; Naser Sadeghian

International Journal of Cancer Management

The Official Journal of Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences

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Survey on Childhood Solid Malignant Tumors in Cases Admitted to Mofid Pediatric Hospital From 1996-2010: a Single-Center Study

Author(s):

Farzaneh Jadali^1,*,

Hosein Aghayan Golkashani¹,

Golareh Habibi²,

Mohsen Rouzrokh³,

Fatemeh Abdollah Gorji⁴,

Fahimeh Dini¹,

Malihe Khodami¹,

Yalda Nilipour¹,

Ahmad Khaleghnejad Tabari³,

Naser Sadeghian³

1Dept. of Pediatric Pathology, Medical Research and Development Center of Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2School of Public Health, Faculty of Health Sciences, Simone Fraser University, Vancouver, British, Colombia

3Dept. of Pediatric Surgery, Medical Research and Development Center of Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

4Medical Research and Development Center of Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

International Journal of Cancer Management:Vol. 5, issue 2; e80920

Published online:Jun 30, 2012

Article type:Research Article

Received:Nov 17, 2011

Accepted:Feb 13, 2012

How to Cite:Farzaneh Jadali Hosein Aghayan GolkashaniGolareh HabibiMohsen RouzrokhFatemeh Abdollah GorjiFahimeh DiniMalihe KhodamiYalda NilipourAhmad Khaleghnejad TabariNaser Sadeghianet al.Survey on Childhood Solid Malignant Tumors in Cases Admitted to Mofid Pediatric Hospital From 1996-2010: a Single-Center Study.Int J Cancer Manag.5(2):e80920.

Abstract

Background: As children comprise a considerable proportion of our population, the importance of local epidemiologic research and geographic and racial differences can’t be disputed on childhood malignancies.

Methods: In this descriptive retrospective study, we extensively reviewed the medical records of patients younger than 15 years of age, diagnosed with solid malignant tumors, from 1996 to 2010, using the last version of International Classification of Childhood Cancers.

Results: In our study the order of incidence of solid malignancies was relatively similar to the other national studies, with lymphomas and Central Nervous System (CNS) tumors as the most common, followed by Sympathetic Nervous System (SNS) tumors, soft tissue sarcomas and renal tumors. The peak age of diagnosis was between 1 and 4 years old. In our study, the overall male to female ratio was 1.38, with a trend towards male dominance in the older age groups. We also observed a disturbing trend of childhood solid malignancies. The total number of cases almost doubled from 2009(54(6.9%)) to 2010(96(12.2%)) .This trend was particularly detected in CNS and SNS tumors. Further analysis showed that malignant CNS tumors had played a more pronounced role in this change.

Conclusion: Changes in trends of some tumor categories have illustrated a desperate need to further research in regional and national levels. Also the gathered data can be used to make more accurate programs for a better control of cancer and to help policymakers to allocate more evidence-based resource for hospitals.

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