Existence of Inhibin ?-Subunit Gene Mutation in a Population of Iranian Women with Premature Ovarian Failure

authors:

avatar M Fallahian 1 , avatar F Pouresmaeili 2 , * , avatar F Azizi 1 , avatar M R Zali 3 , avatar E M Samani 1 , avatar P Kharaziha 3

Department of Obstetrics and Gynecology,Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, I.R.Iran
Department of Genetics, and Infertility & Reproductive Health Research Center(IRHRC), Taleghani Hospital, Shahid Beheshti University of Medical Sciences, fpoures@yahoo.com, I.R.Iran
Research center for gastroenterology and liver diseases, Taleghani Hospital, Shahid Beheshti University of MedicalmSciences, IR.Iran
International Journal of Endocrinology and Metabolism: Vol.7, issue 2; 67-71
article type: Original Article
received: January 1, 2008
accepted: May 20, 2009

how to cite: Fallahian M, Pouresmaeili F, Azizi F, Zali M, Samani E, et al. Existence of Inhibin ?-Subunit Gene Mutation in a Population of Iranian Women with Premature Ovarian Failure. Int J Endocrinol Metab. 2009;7(2): 67-71. 

Abstract

Premature ovarian failure (POF) is characterized by hypergonadotropic amenorrhea, before the age of 40, for which the Inhibin α-subunit (INHα) gene is proposed as a candidate gene, due to its role in negative feedback control of FSH. In this study we aimed at demonstrating the candidate mutation as a gene variation associated with POF in Iranian population. Materials & Methods: Using DNA sequencing, DNA samples of 24 women with POF and 24 controls, aged below 40 years, were screened for mutations in the Inhibin gene. Results: The 769G→A mutation in exon 2 of the Inhibin-α gene was found in four out of 24 idi-opathic POF patients. Conclusion: The results obtained in this study have shown that this variation is more frequent in patients with POF than in normal fertile pop-ulations of Iran.

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