Helicobacter pylori (H. pylori) is a Gram-negative bacillus responsible for one of the most commonly diagnosed infections in humans worldwide. It is recognized to be associated closely with gastric and duodenal ulcers in adults and children (1, 2). Helicobacter pylori persistently colonizes the human stomach, induces inflammatory cytokines, and causes gastric inflammation and then increases gastric acid production (1, 3). Sometimes, H. pylori can cause pan gastritis with decreased gastric acid production and gastric atrophy. The prevalence rate is different from 10 to 60% according to developed or under developing countries. Crowding and poor personal hygiene play an important role in person-to-person transmission of H. pylori infection and also socio-economic level is strongly related to the prevalence of H. pylori infection, an important finding that may also reflect the same factors as those noted in developing countries. In these situations, infection clusters are reported, particularly in families with infected children. The possible routes are fecal-oral and oral-oral (1, 2). Nonsteroidal anti-inflammatory drugs (NSAIDs) are also well-established risk factors for the development of uncomplicated and complicated gastric ulcers. Evidence suggests the use of NSAIDs, especially in patients with H. pylori infection can cause the chance of gastric and duodenal ulcers. On the other hand, coprescription of NSAIDs with proton-pump inhibitors (PPIs) reduces gastroduodenal lesions. NSAID-naive users benefit from testing for H. pylori infection and, if positive, H. pylori eradication therapy is recommended prior to the initiation of NSAID (1, 4). There are studies showing that the interaction between H. pylori and NSAIDs in ulcer development maybe synergistic. Chan (3) showed that H. pylori eradication is essential to prevent peptic ulcers caused by the use of nonsteroidal anti-inflammatory drugs, whose risk is reduced by almost four-fold after the disappearance of the H. pylori infection. Some researchers reported that PPI therapy is superior to the eradication of H. pylori for the secondary prevention of upper gastrointestinal bleeding in patients with H. pylori who continue to take NSAIDs (1, 3-6). It is clear that, ulcer risk reduction after H. pylori eradication therapy is more marked in patients starting to use NSAIDs than in patients who receive NSAIDs without eradication therapy. In some countries, like our region, self-medication is common and some patients, who suffer from any pain, use the NSAIDs even with high dose. Moreover, some pharmacies offer these drugs without any prescription to patients. Hence, the rate of infection is high in this area and also using NSAIDs and aspirin in this situation can cause peptic ulcer and hemorrhage. Therefore, we must acknowledge patients about this issue.
International Journal of High Risk Behaviors and Addiction
Outlines
Self-Medication With Analgesics and Helicobacter pylori Infection
Author(s):
1Infectious Diseases and Tropical Medicine Research Center, Boo-Ali Hospital, Zahedan University of Medical Sciences, Zahedan, IR Iran
Published online:Jun 20, 2015
Article type:Editorial
Received:Dec 06, 2014
Accepted:Dec 27, 2014
How to Cite:Maliheh MetanatSelf-Medication With Analgesics and Helicobacter pylori Infection.Int J High Risk Behav Addict.2015;4(2):e26155.https://doi.org/10.5812/ijhrba.4(2)2015.26155.
References
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- 4.Boltin D, Niv Y. Pharmacological and alimentary alteration of the gastric barrier. Best Pract Res Clin Gastroenterol. 2014;28(6):981-94. [PubMed ID: 25439065]. https://doi.org/10.1016/j.bpg.2014.09.001.
- 5.Gargallo CJ, Sostres C, Lanas A. Prevention and Treatment of NSAID Gastropathy. Curr Treat Options Gastroenterol. 2014;12(4):398-413. [PubMed ID: 25209136]. https://doi.org/10.1007/s11938-014-0029-4.
- 6.Lim YJ, Hong SJ. Helicobacter pylori infection in nonsteroidal anti-inflammatory drug users. Korean J Gastroenterol. 2014;64(2):70-5. [PubMed ID: 25168047].
Copyright
Copyright © 2015, Zahedan University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
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