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Cost-Safety-Effectiveness Analysis of Different Methods of Rabies Vaccination

Author(s):
Beuy JoobBeuy Joob1,*, Viroj WiwanitkitViroj Wiwanitkit2
1Medical Center, Sanitation One Medical Academic Center, Bangkok, Thailand
2Tropical Medicine Unit, Hainan Medical University, Bangkok, Thailand


International Journal of Infection:Vol. 3, issue 1; e32622
Published online:Nov 15, 2015
Article type:Letter
Received:Aug 21, 2015
Accepted:Aug 23, 2015
How to Cite:Beuy JoobViroj WiwanitkitCost-Safety-Effectiveness Analysis of Different Methods of Rabies Vaccination.Int J Infect.2015;3(1):e32622.https://doi.org/10.17795/iji-32622.

Dear Editor,

Rabies is a deadly neurological disease. The best prevention is post exposure rabies vaccination (1). In the present day, there are several techniques for vaccine administration. Both intradermal (ID) and intramuscular (IM) administration can be used and different numbers of injection site is applicable. There are some reports comparing the effectiveness of different techniques. The recent publication by Warrell et al. compared several techniques and can be useful for further policy making (2). Nevertheless, the important concern in decision making is “cost” and “effectiveness”. In addition, “safety” has to be considered. Here, the author performed an analysis on cost-safety-effectiveness analysis of different methods of rabies vaccination. Data on cost refers to the standard vaccine cost, in US dollar, from the Red Cross Society, Thailand. The effectiveness and safety refer to the published data by Warrell et al. (2). The cost-safety-effectiveness analysis can be defined as cost per safe fraction of vaccine effectiveness, which can be calculated using the following equation:

The data of analysis is shown in Table 1. According to the analysis, in terms of cost, effectiveness and safety, the 2-site ID regimen is the most favorable method with the lowest cost and highest safe effectiveness.

Table 1. Cost-Safety-Effectiveness Analysis
RegimensCost (USD) aEffectivenessbPercent of Adverse EffectsCost-Safety-Effectiveness
1-site IM301.3362.560.15
2-site ID124.6093.137.81
4-site ID122.52100Non calculable
8-site ID123.2196.7113.28

Cost-Safety-Effectiveness Analysis

References

  • 1.
    Bader MS, McKinsey DS. Postexposure prophylaxis for common infectious diseases. Am Fam Physician. 2013;88(1):25-32. [PubMed ID: 23939603].
  • 2.
    Warrell MJ, Riddell A, Yu LM, Phipps J, Diggle L, Bourhy H, et al. A simplified 4-site economical intradermal post-exposure rabies vaccine regimen: a randomised controlled comparison with standard methods. PLoS Negl Trop Dis. 2008;2(4). eee224. [PubMed ID: 18431444]. https://doi.org/10.1371/journal.pntd.0000224.
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