Clinical Significance of the Dynamic Changes in Serum Eotaxin, Interleukin 13 and Total IgE in Children with Bronchial Asthma

Xin  Wang; Chunyan Ma; Yajing Zhang; Lihua Ning; Hua Chen; Fang Zhou

IJ Pediatrics

The Scientific Journal of Growth & Development Research Center

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Clinical Significance of the Dynamic Changes in Serum Eotaxin, Interleukin 13 and Total IgE in Children with Bronchial Asthma

Author(s):

Xin Wang^1,*,

Chunyan Ma²,

Yajing Zhang³,

Lihua Ning⁴,

Hua Chen⁵,

Fang Zhou⁶

IJ Pediatrics:Vol. 23, issue 5; 525-530

Published online:Aug 13, 2013

Article type:Research Article

Received:Nov 26, 2012

Accepted:Jul 24, 2013

How to Cite:Xin WangChunyan MaYajing ZhangLihua NingHua ChenFang Zhouet al.Clinical Significance of the Dynamic Changes in Serum Eotaxin, Interleukin 13 and Total IgE in Children with Bronchial Asthma.Iran J Pediatr.23(5):525-530.

Abstract

Objective: To determine the serum levels of eotaxin, IL-13 and total IgE (TIgE) in asthmatic children during the acute and clinical remission periods, as well as the changes in pulmonary function to determine their roles, relationships and clinical significance during asthma exacerbation. Methods: A total of 30 asthmatic children and 22 healthy children were enrolled in the study. The serum eotaxin and IL-13 levels were detected using an enzyme-linked immunosorbent assay and the TIgE level was detected using a fluorescent enzyme-linked immunosorbent assay. The asthmatic children were subjected to pulmonary function tests. Findings: The serum eotaxin, IL-13 and TIgE levels of the asthmatic children during the acute period significantly differed from those during clinical remission. The serum eotaxin, IL-13 and TIgE levels of the asthmatic children during both periods significantly differed from those of healthy children (P

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