Familial History and Recurrence of Febrile Seizures; a Systematic Review and Meta-Analysis

Kourosh Sayehmiri; Yousef Veisani; Ali Delpisheh

IJ Pediatrics

The Scientific Journal of Growth & Development Research Center

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Familial History and Recurrence of Febrile Seizures; a Systematic Review and Meta-Analysis

Author(s):

Kourosh Sayehmiri^1,*,

Yousef Veisani²,

Ali Delpisheh³

IJ Pediatrics:Vol. 23, issue 4; 389-395

Published online:Apr 11, 2013

Article type:Brief Report

Received:Jul 02, 2012

Accepted:Apr 07, 2013

How to Cite:Kourosh SayehmiriYousef VeisaniAli DelpishehFamilial History and Recurrence of Febrile Seizures; a Systematic Review and Meta-Analysis.Iran J Pediatr.23(4):389-395.

Abstract

Objective: Febrile seizure (FS) as the most common form of seizures in childhood, affects 2-5% of all children across the world. The present study reviews available reports on FS recurrence frequency and evaluates its associated risk factors in Iran. Methods: We searched the Persian database such as: SID, MagIran, Medlip, Irandoc, Iranmedex as well as English databases PubMed, ISI, and Scopus. Random effects models were used to calculate 95% confidence intervals. Meta regression was introduced to explore the heterogeneity between studies. Findings: The overall FS recurrence rate was 20.9% [95% confidence interval (CI): 12.3-29.5%]. The frequency of FS simple and complex types was 69.3% (95% CI: 59.5-79.0) and 25.3% (95% CI: 19.6-31.0), respectively. A positive familial history of 28.8% (95% CI: 19.3-38.4%) was observed for childhood FS including 36.2% (95% CI: 27.3-39.6%) for the simple and 29.4% (95% CI: 23.1-33.5%) for the complex type. The heterogeneity of recurrent FS was significantly affected by sample size (P=0.026). Conclusion: Almost one-third of FS children had a positive familial history. The increased risk of recurrence in patients with symptomatic seizures needs to be fully considered by parents, physicians, nurses and health policy makers.

Keywords

Febrile seizure

Recurrence

Positive familial History

Systematic review

Meta-Analysis

Iran

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