Investigation of the Relationship Between Retinol Binding Protein 4, Metabolic Syndrome and Insulin Resistance in Iranian Obese 5-17 Year Old Children

Zohreh Karamizadeh; Forough Saki; Soheil Ashkani-Esfahani

IJ Pediatrics

The Scientific Journal of Growth & Development Research Center

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Investigation of the Relationship Between Retinol Binding Protein 4, Metabolic Syndrome and Insulin Resistance in Iranian Obese 5-17 Year Old Children

Author(s):

Zohreh Karamizadeh^1,*,

Forough Saki²,

Soheil Ashkani-Esfahani³

IJ Pediatrics:Vol. 23, issue 4; 396-402

Published online:Jul 02, 2013

Article type:Research Article

Received:Mar 09, 2015

Accepted:May 12, 2013

How to Cite:Zohreh KaramizadehForough SakiSoheil Ashkani-EsfahaniInvestigation of the Relationship Between Retinol Binding Protein 4, Metabolic Syndrome and Insulin Resistance in Iranian Obese 5-17 Year Old Children.Iran J Pediatr.23(4):396-402.

Abstract

Objective: Retinol-binding protein 4 (RBP4) has recently been reported to be associated with insulin resistance (IR) and the metabolic syndrome by a number of researchers in various populations. However, controversies are present among different studies, which might be due to the differences between various ethnic, age, and sex groups. This study aimed to determine whether RBP4 can be assumed as a marker of IR and the metabolic syndrome in the Iranian obese children. Methods: In the present longitudinal cross-sectional study, 100 5-17 years old obese children were recruited from January 1, 2011 to February 1, 2012. The patients’ information including the demographic variables, health status and behavior, and daily physical activity were collected. Moreover, serum RBP4 was measured and correlated with the homeostasis model assessment of IR index (HOMA-IR), components of the metabolic syndrome, and lipoprotein metabolism. Findings: The results revealed a positively significant correlation between RBP4 and the HOMA-IR index (P=0.02). Partial Spearman test also revealed a significant correlation between RBP4 plasma concentrations and the components of the metabolic syndrome, including waist circumference, systolic (but not diastolic) blood-pressure, and fasting blood sugar (P

Keywords

Retinol Binding Protein 4

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