Combination of Probiotics and Antibiotics in the Prevention of Recurrent Urinary Tract Infection in Children

authors:

avatar Abdol-Mohammad Kajbafzadeh 1 , * , avatar Mohammad-Javad Mohseni 2 , avatar Zahra Aryan 3 , avatar Sahra Emamzadeh-Fard 4 , avatar Koosha Paydary 5 , avatar Vahid Mofid 6 , avatar Hasan Joudaki 7

Iranian Journal of Pediatrics: Vol.23, issue 4; 430-438
published online: April 26, 2013
article type: Research Article
received: February 28, 2013
accepted: April 05, 2013

how to cite: Kajbafzadeh A, Mohseni M, Aryan Z, Emamzadeh-Fard S, Paydary K, et al. Combination of Probiotics and Antibiotics in the Prevention of Recurrent Urinary Tract Infection in Children. Iran J Pediatr. 2013;23(4): 430-438. 

Abstract

Objective: We examined the preventive effect of probiotic and antibiotics versus antibiotics alone, in children with recurrent urinary tract infections (RUTI) in a preliminary randomized clinical trial. Methods: Between March 2007 and April  2011, children with the history of RUTI and unilateral vesicoureteral reflux (VUR) were randomly assigned to receive  concomitant probiotic and antibiotics (Lactobacillus acidophilus and bifidobacterium lactis, 107/ml, as 0.25 ml/kg three times a day regimen in addition to Nitrofurantoin, 1mg/kg daily (group I). In group II, all children received conventional prophylactic antibiotics alone (Nitrofurantoin, 1 mg/kg daily). Randomization was performed via using the random numerals table in a 1:1 manner with stratification by sex, age and grade of reflux. The urine examinations were done monthly and the incidence of UTI was evaluated in these two groups. Findings: Forty-one children (age: 8.3±3.1 years) in group I and 44 children (age: 8.0±3.0 years) in group II were compared. During the course of three years, 39% in group I and 50% of participants in group II experienced RUTIs (P=0.4). Incidences of UTI - febrile and afebrile - reduced in both groups without any significant differences after two years of prophylaxis. Also, incidence of afebrile UTIs did not significantly differ (0.51±1.30 and 0.81±1.41 respectively, P=0.3); however, the incidence of febrile UTIs in particular were lower in group I (0.00±0.00 versus 0.13±0.40, P=0.03) in the last year. Conclusion: The consumption of probiotic and antibiotics in children with RUTI is safe and more effective in reducing the incidence of febrile UTI in comparison to prophylactic antibiotics alone.
 

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