Outcome of Vesicoureteral Reflux in Infants: Impact of Prenatal Diagnosis

Hamid Mohammadjafari; Alireza Alam; Saeed Mohammadi; Seyed-Abdollah Mousavi; Ahmadshahab Kosaryan; Mohammad Khademloo; Mohammad Abedi

IJ Pediatrics

The Scientific Journal of Growth & Development Research Center

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Outcome of Vesicoureteral Reflux in Infants: Impact of Prenatal Diagnosis

Author(s):

Hamid Mohammadjafari^1,*,

Alireza Alam²,

Saeed Mohammadi³,

Seyed-Abdollah Mousavi⁴,

Ahmadshahab Kosaryan⁵,

Mohammad Khademloo⁶,

Mohammad Abedi⁷

IJ Pediatrics:Vol. 23, issue 4; 439-444

Published online:Jul 13, 2013

Article type:Research Article

Received:Dec 21, 2012

Accepted:Apr 07, 2013

How to Cite:Hamid MohammadjafariAlireza AlamSaeed MohammadiSeyed-Abdollah MousaviAhmadshahab KosaryanMohammad KhademlooMohammad Abediet al.Outcome of Vesicoureteral Reflux in Infants: Impact of Prenatal Diagnosis.Iran J Pediatr.23(4):439-444.

Abstract

Objective: Vesicoureteral reflux (VUR) is an important disorder that could be diagnosed in antenatal or postnatal period. The natural history of VUR seems to be different between prenatal or postnatal forms of the disease. We compared the natural history and outcome of vesicoureteral reflux in infants less than one year old diagnosed prenatally or postnatally. Methods: All infants less than 12 months old with VUR were enrolled in two groups. Group 1 composed of patients with antenatal hydronephrosis and group2, infants with diagnosis of VUR because of UTI or other postnatal problems. We followed patients for an average of 33 months. Outcome was assessed by several factors: somatic growth, need for surgery, resolution, occurrence of UTI and scar formation. Findings: We studied 236 renal units in 152 patients (70 boys, 82girls), 67 patients in group 1 and 85 patients in group2. Occurrence of recurrent UTI was 10.6% with no significant difference between two groups. Reflux resolved in postnatal group more significantly than in the other group (73% vs 49%). Scar developed similarly in both groups (15% vs 25% of renal units). Surgery performed in 7 (8.2%) of postnatal and 4 (6%) of prenatal group with no significant differences between the two groups. Conclusion: VUR diagnosed prenatally has similar importance and outcome as postnatal diagnosed one. We suggest performing the same imaging and treatment procedures for prenatally and postnatally diagnosed VUR.

Keywords

Vesicoureteral Reflux

Hydronephrosis

Urinary Tract Infection

Renal Scaring

Prenatal Diagnosis

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