Olfactory Stimulation by Vanillin Prevents Apnea in Premature Newborn Infants

Mitra Edraki; Hajar Pourpulad; Marzie Kargar; Narjes Pishva; Najaf Zare; Hashem Montaseri

IJ Pediatrics

The Scientific Journal of Growth & Development Research Center

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Olfactory Stimulation by Vanillin Prevents Apnea in Premature Newborn Infants

Author(s):

Mitra Edraki^1,*,

Hajar Pourpulad²,

Marzie Kargar³,

Narjes Pishva⁴,

Najaf Zare⁵,

Hashem Montaseri⁶

IJ Pediatrics:Vol. 23, issue 3; 261-268

Published online:Mar 01, 2013

Article type:Research Article

Received:Mar 06, 2012

Accepted:Jan 25, 2013

How to Cite:Mitra EdrakiHajar PourpuladMarzie KargarNarjes PishvaNajaf ZareHashem Montaseriet al.Olfactory Stimulation by Vanillin Prevents Apnea in Premature Newborn Infants.Iran J Pediatr.23(3):261-268.

Abstract

Objective: Apnea is one of the most common problems in premature newborns. The present study aimed to determine the effect of olfactory stimulation by vanillin on prevention of apnea in premature newborns. Methods: In this randomized controlled trial, 36 premature newborns with the postnatal age of 2 days and weight under 2500 grams referred to the hospitals affiliated to Shiraz University of Medical Sciences, were selected through simple random sampling and allocated into control and experimental groups. The experimental group received olfactory stimulation by saturated vanillin solution, while the control group received no interventions. The newborns of both groups were continuously monitored for presence/absence of apnea and number of episodes of apnea as well as arterial blood oxygen saturation and heart rate for 5 days. The data were analyzed by independent Student t-test and repeat measure ANCOVA. Findings: The presence of apnea revealed to be significantly different between the two groups in the first, second, and fourth day of the study (P

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