Adiponectin is a Good Marker for Metabolic State among Type 1 Diabetes Mellitus Patients

Hamdollah Karamifar; Narges Habibian; Gholamhosein Amirhakimi; Zohre Karamizadeh; Abbas Alipour

IJ Pediatrics

The Scientific Journal of Growth & Development Research Center

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Adiponectin is a Good Marker for Metabolic State among Type 1 Diabetes Mellitus Patients

Author(s):

Hamdollah Karamifar¹,

Narges Habibian^2,*,

Gholamhosein Amirhakimi³,

Zohre Karamizadeh⁴,

Abbas Alipour⁵

IJ Pediatrics:Vol. 23, issue 3; 295-301

Published online:Apr 11, 2013

Article type:Research Article

Received:Apr 06, 2012

Accepted:Mar 06, 2013

How to Cite:Hamdollah KaramifarNarges HabibianGholamhosein AmirhakimiZohre KaramizadehAbbas AlipourAdiponectin is a Good Marker for Metabolic State among Type 1 Diabetes Mellitus Patients.Iran J Pediatr.23(3):295-301.

Abstract

Objective: Adiponectin is secreted from adipose tissue. This hormone has a fundamental role in pathogenesis of insulin resistance, and has anti-inflammatory and anti-atherogenic effects. The objectives of this study were to compare serum adiponectin level between type 1 diabetics and healthy people and to assess its related factors, and also to determine the relationship between adiponectin and metabolic state.
Methods: This was a case control study involving 60 diabetics (25 good and 35 poor metabolic controlled) and 28 healthy persons (younger than 18 years old). The data about demographic (age and sex), clinical and paraclinical characteristics [body mass index (BMI), duration of disease, puberty state, and glycosylated hemoglobin (HbA1c) and adiponectin level in serum] were collected. Determinants of adiponectin were assessed using univariate and multiple linear regression analyses.
Findings: Mean (±SD) serum adiponectin level in healthy persons, good-controlled and poor-controlled type 1 diabetes mellitus patients were 9.16 (±4.2) μg/cc, 10.89 (±4.48)μg/cc, and 15.92 (±8.26)μg/cc, respectively. Post hoc analysis revealed that differences of adiponectin between poor- and good-controlled type 1 diabetes mellitus patients (P=0.01) and between healthy persons and poor controlled type 1 diabetes mellitus (P<0.0001) were statistically significant. Adiponectin level was associated with puberty state and BMI in healthy persons. It was associated with puberty state and HbA1c in type 1 diabetic persons.
Conclusion: Serum level of adiponectin was higher in type 1 diabetics than in healthy persons and it can be used as a good marker for metabolic control state among diabetics.

Keywords

Cytokines

Adiponectin

Type 1 Diabetes Mellitus

Glycosylated Hemoglobin

Puberty

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