Expression of T-cell Immunoglobulin- and Mucin-domain-containing Molecule-3 on Lymphocytes from Henoch-Schoenlein Purpura Patients

Yuan Li-ping; Yan Bo; Lu Ling; Hu Bo

IJ Pediatrics

The Scientific Journal of Growth & Development Research Center

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Expression of T-cell Immunoglobulin- and Mucin-domain-containing Molecule-3 on Lymphocytes from Henoch-Schoenlein Purpura Patients

Author(s):

Yuan Li-ping^1,*,

Yan Bo²,

Lu Ling³,

Hu Bo⁴

IJ Pediatrics:Vol. 23, issue 3; 345-348

Published online:Feb 06, 2013

Article type:Brief Report

Received:May 16, 2012

Accepted:Jan 23, 2013

How to Cite:Yuan Li-pingYan BoLu LingHu BoExpression of T-cell Immunoglobulin- and Mucin-domain-containing Molecule-3 on Lymphocytes from Henoch-Schoenlein Purpura Patients.Iran J Pediatr.23(3):345-348.

Abstract

Objective: To investigate T-cell immunoglobulin domain and mucin domain-containing molecule-3 (Tim-3) and its ligand galectin-9 mRNA expression in peripheral blood mononuclear cells (PBMCs) from Henoch-Schoenlein Purpura (HSP) patients.
Methods: Quantitative real-time reverse transcription-polymerase chain reaction (PCR) was used to examine the mRNA expression of Tim-3 and its ligand galectin-9 in PBMCs from HSP patients. ELISA methods were used to examine the levels of serum IFN-γ and immunoglobulin A1 (IgA1). The Spearman rank test was used for correlation analysis between Tim-3, galectin-9 mRNA expression and serum IFN-γ and IgA1 levels, respectively.
Findings: The results showed that Tim-3 and galectin-9 mRNA expression was obviously higher in patients, which was closely correlated with serum IFN-γ and IgA1, respectively.
Conclusion: The results suggested that Tim-3/Tim-3L may be related to the pathogenesis of HSP.

Keywords

Henoch-Schoenlein Purpura

T-cell Immunoglobulin

Mucin domain containing 3 protein

TIM-3 protein

Immunoglobulin A

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