The Investigation of Effects of Blood Exchange Transfusion on Selenium in Newborn Infants by Instrumental Neutron Activation Analysis Method

Seyedeh-Fatemeh  Khatami; Pouya Parvaresh; Parviz Parvaresh; Morteza Gharib

IJ Pediatrics

The Scientific Journal of Growth & Development Research Center

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The Investigation of Effects of Blood Exchange Transfusion on Selenium in Newborn Infants by Instrumental Neutron Activation Analysis Method

Author(s):

Seyedeh-Fatemeh Khatami^1,*,

Pouya Parvaresh²,

Parviz Parvaresh³,

Morteza Gharib⁴

IJ Pediatrics:Vol. 23, issue 2; 131-137

Published online:Dec 24, 2012

Article type:Research Article

Received:Jul 23, 2012

Accepted:Nov 17, 2012

How to Cite:Seyedeh-Fatemeh KhatamiPouya ParvareshParviz ParvareshMorteza GharibThe Investigation of Effects of Blood Exchange Transfusion on Selenium in Newborn Infants by Instrumental Neutron Activation Analysis Method.Iran J Pediatr.23(2):131-137.

Abstract

Objective: The evidence for the effects of blood exchange transfusion on selenium (Se) in newborn infants is unknown. This study was conducted to determine the possible effects of blood exchange transfusion on Se by comparing the Se blood concentrations before and after exchange transfusion in jaundiced neonates.
Methods: A total of 30 jaundiced term neonates who underwent blood exchange transfusion (EXT) for first time because of idiopathic unconjugated hyperbilirubinemia, were recruited. The Se level of 30 blood bank donors’ samples used for EXT were measured and 30 pairs of uncontaminated umbilical cord blood samples were investigated for Se before and after exchange transfusion. The samples were analyzed by instrumental neutron activation analysis method. Serum bilirubin concentrations were measured by venous blood samples before EXT.
Findings: The average of Se concentration before EXT was higher than that after EXT (629.78±283.82 SD ppb versus 454.83±213.75 SD ppb) (P<0.05). There was significant correlation between the blood concentration of Se before and after EXT and also between the blood level of Se before EXT and total serum bilirubin level (P<0.05). There was no significant correlation between the blood concentration of Se before EXT and babies’ gender and weight (P>0.05). The average Se level in samples obtained from transfused blood products was 507.90±223.56 SD ppb.
Conclusion: Blood exchange transfusion caused a 28% decrease of the blood Se level because the blood donors had lower blood Se levels than the newborns. Furthermore, there was a significant correlation between the blood level of Se before EXT and the total serum bilirubin level.

Keywords

Trace elements

Exchange transfusion

Newborn

Neutron activation analysis

Selenium

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