Tuberous Sclerosis Complex in Autism

Xiao-Dong Shi; Wen-Jun Tu; Xin Guo

IJ Pediatrics

The Scientific Journal of Growth & Development Research Center

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Tuberous Sclerosis Complex in Autism

Author(s):

Xiao-Dong Shi¹,

Wen-Jun Tu¹,

Xin Guo^2,*

1Department of Clinical laboratory, China Rehabilitation Research Center, Beijing, China

2Department of Clinical laboratory, The First Affiliated Hospital of Harbin Medical University, Harbin, China, China

IJ Pediatrics:Vol. 22, issue 3; 408-411

Published online:Sep 30, 2012

Article type:Brief Report

Received:Jul 09, 2011

Accepted:Mar 05, 2012

How to Cite:Xiao-Dong ShiWen-Jun TuXin GuoTuberous Sclerosis Complex in Autism.Iran J Pediatr.22(3):408-411.

Abstract

Objective: To study the prevalence rate of tuberous sclerosis complex in autistic disorder.
Methods: We studied one cohort of children followed up since 2005 until 2009, with autistic disorder, to determine the incidence of tuberous sclerosis complex. We established an autistic disorder registry in 2005 at China Rehabilitation Research Center. During the 4-year period (2005–2009), we collected a database of 429 children (390 boys and 39 girls; male to female ratio 10:1) with autistic disorder and pervasive developmental disorders. We routinely examined all children with autistic disorder for any features of tuberous sclerosis complex by looking for neurocutaneous markers such as depigmented spots. In those with infantile spasm or epilepsy, the clinical features of tuberous sclerosis complex were monitored regularly during follow-up.
Findings: Of these, five had tuberous sclerosis complex. Thus, the prevalence rate of tuberous sclerosis complex in autistic disorder is 1.17%. All of these children were mentally retarded with moderate to severe grades. Their IQ or developmental quotient was less than 70.
Conclusion: The prevalence rate of tuberous sclerosis complex in autistic disorder was 1.17% in our region; autism spectrum disorder is a condition that might be associated with development of tuberous sclerosis complex.

Keywords

Tuberous Sclerosis Complex

Autism

Autistic Disorder

Neurocutaneous Syndromes

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