Platelets in Pulmonary Hypertension: a Causative Role or a Simple Association?

Keyhan  Sayadpour Zanjani

IJ Pediatrics

The Scientific Journal of Growth & Development Research Center

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Platelets in Pulmonary Hypertension: a Causative Role or a Simple Association?

Author(s):

Keyhan Sayadpour Zanjani^1,*

1Pediatric Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran

IJ Pediatrics:Vol. 22, issue 2; 145-157

Published online:Jun 30, 2012

Article type:Review Article

Received:Sep 05, 2011

Accepted:Feb 11, 2012

How to Cite:Keyhan Sayadpour ZanjaniPlatelets in Pulmonary Hypertension: a Causative Role or a Simple Association?.Iran J Pediatr.22(2):145-157.

Abstract

Pathophysiology of pulmonary arterial hypertension is based on three basic mechanisms: thrombotic pulmonary vascular lesions, vasoconstriction and vascular remodeling. Platelets are related to all of these mechanisms by their aggregation, production, storage and release of several mediators. The role of platelets is more prominent in some types of pulmonary arterial hypertension, including those which are secondary to inflammatory and infectious diseases, hemoglobinopathies, essential thrombocythemia, drugs, thrombo-embolism, and cardiac surgery. Most pulmonary antihypertensive drugs have a negative effect on platelets. In this review, the mechanisms of platelets association with pulmonary arterial hypertension, those types of pulmonary arterial hypertension with greatest platelet contribution to their pathophysiology, and the effects of pulmonary antihypertensive drugs on platelets are summarized.

Keywords

Platelet

Pulmonary Hypertension

Pulmonary Vascular Resistance

Vasoconstriction

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