Polyamine Oxidase and Diamine Oxidase Activities in Human Milk during the First Month of Lactation

Dusica Stojanović; Marina Jonovic; Stevo Najman; Bojko Bjelakovic; Zoran Pop-Trajkovic; Gordana Kocic; Ljiljana Bjelakovic

IJ Pediatrics

The Scientific Journal of Growth & Development Research Center

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Polyamine Oxidase and Diamine Oxidase Activities in Human Milk during the First Month of Lactation

Author(s):

Dusica Stojanović¹,

Marina Jonovic²,

Stevo Najman³,

Bojko Bjelakovic⁴,

Zoran Pop-Trajkovic²,

Gordana Kocic⁵,

Ljiljana Bjelakovic^4,*

1Department of Hygiene, Faculty of Medicine, University of Nis, Serbia

2Clinical Center, Clinic of Obstetrics and Gynecology, Nis, Serbia

3Institute of Genetics, Faculty of Medicine, University of Nis, Serbia

4Department of Hygiene, Faculty of Sport and Physical Education, University of Nis, Serbia

5Department of Biochemistry, Faculty of Medicine, University of Nis, Serbia

IJ Pediatrics:Vol. 22, issue 2; 218-222

Published online:Jun 30, 2012

Article type:Research Article

Received:Dec 22, 2008

Accepted:Jul 06, 2009

How to Cite:Dusica StojanovićMarina JonovicStevo NajmanBojko BjelakovicZoran Pop-TrajkovicGordana KocicLjiljana Bjelakovicet al.Polyamine Oxidase and Diamine Oxidase Activities in Human Milk during the First Month of Lactation.Iran J Pediatr.22(2):218-222.

Abstract

Objective: Human milk (HM) is the ideal food for all newborns and infants. Apart from various bioactive compounds, including cytokines, antibodies, hormones, vitamines, it also contains polyamines, such as spermine (Sp), spermidine (Spd) and putrescine (Put).
Aim: The present study investigated polyamine metabolism in colostrum and mature human milk by measuring the polyamine oxidase (PAO) and diamine oxidase (DAO) enzyme activities, which are necessary for polyamine catabolism, as well as by determining the malondialdehyde (MDA) levels, the final product of polyamine biodegradation.
Methods: The PAO, DAO activity and MDA levels were quantified in colostrum (1st and 2nd day) as well as in mature human milk, 30th day of lactation.
Findings: We found the steady increase of PAO activity and steady decrease of DAO activity and MDA levels during first month of lactation.
Conclusion: Since the products of PAO activity such as, amino aldehydes and hydrogen peroxide (H2O2) might have potential antimicrobial effects, promoting the oxidative stress, it is likely that human milk PAO throughout the lactation period, contributes to the protective effects of human milk.

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