Can Urinary Nitrite Results Be Used to Conduct Antimicrobial Option for Urinary Tract Infection in Children?

Ameneh Barikani; Mohammad-Mahdi Daneshi-Kohan; Mahta Froozesh; Parviz Ayazi; Abolfazl Mahyar

IJ Pediatrics

The Scientific Journal of Growth & Development Research Center

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Can Urinary Nitrite Results Be Used to Conduct Antimicrobial Option for Urinary Tract Infection in Children?

Author(s):

Ameneh Barikani¹,

Mohammad-Mahdi Daneshi-Kohan²,

Mahta Froozesh³,

Parviz Ayazi³,

Abolfazl Mahyar^3,*

1Department of Social Sciences, Qazvin university of Medical Sciences, Qazvin, Iran

2Department of Diagnostic laboratory Medicine, Qazvin university of Medical Sciences, Qazvin, Iran

3Department of Pediatrics, Qazvin university of Medical Sciences, Qazvin, Iran

IJ Pediatrics:Vol. 22, issue 2; 237-240

Published online:Jun 30, 2012

Article type:Research Article

Received:Mar 30, 2011

Accepted:Oct 25, 2011

How to Cite:Ameneh BarikaniMohammad-Mahdi Daneshi-KohanMahta FroozeshParviz AyaziAbolfazl MahyarCan Urinary Nitrite Results Be Used to Conduct Antimicrobial Option for Urinary Tract Infection in Children?.Iran J Pediatr.22(2):237-240.

Abstract

Objective: This study was performed to determine the relationship between urinary nitrite results and bacterial resistance to antimicrobial drugs in urinary tract infection of children.
Methods: In a cross-section study 119 children younger than 12 years with urinary tract infection were evaluated in Qazvin children's hospital. Patients were divided into negative and positive nitrite groups depending on urinary nitrite test result. Rates of antibiotic resistance in the two groups were compared.
Findings: Sixty seven patients were in the negative nitrite group and 52 in the positive nitrite group. Resistance rates to ceftriaxone, trimethoprim sulfamethoxazole, ampicillin, gentamicin, amikacin, nalidixic acid, cephalothin and nitrofurantoin in the nitrite negative group were 7.5%, 31.3%, 50.7%, 11.9%, 9%, 3%, 14.9% and 11.9%, respectively. These values in the nitrite positive group were 21.2%, 28.8%, 63.5%, 7.7%, 5.8%, 1.9%, 9.6%, and 3.8%, respectively (P>0.05).
Conclusion: This study showed that there is no correlation between urinary nitrite results and bacterial resistance to antimicrobial drugs. Therefore, it seems that physicians should not adjust antibiotic therapy for UTI based on nitrite results.

Keywords

Urinary Tract Infections

Nitrite

Anti-bacterial agents

Drug resistance

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