Comparison of Epinephrine to Salbutamol in Acute Bronchiolitis

Mehrshad Arashpour; Jamal Faghihinia; Asadola Asadian; Firoozeh Mousavinasab; Mohammad-Reza  Modaresi

IJ Pediatrics

The Scientific Journal of Growth & Development Research Center

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Comparison of Epinephrine to Salbutamol in Acute Bronchiolitis

Author(s):

Mehrshad Arashpour¹,

Jamal Faghihinia¹,

Asadola Asadian²,

Firoozeh Mousavinasab¹,

Mohammad-Reza Modaresi^3,*

1Child Health Promotion Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

2Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

3Child Health Promotion Research Center, Isfahan University of Medical Sciences, Isfahan & Pediatric Infectious Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran

IJ Pediatrics:Vol. 22, issue 2; 241-244

Published online:Jun 30, 2012

Article type:Research Article

Received:Dec 12, 2010

Accepted:Jun 20, 2011

How to Cite:Mehrshad ArashpourJamal FaghihiniaAsadola AsadianFiroozeh MousavinasabMohammad-Reza ModaresiComparison of Epinephrine to Salbutamol in Acute Bronchiolitis.Iran J Pediatr.22(2):241-244.

Abstract

Objective: An appropriate treatment of acute viral bronchiolitis can reduce the symptoms, hospitalization duration and exorbitant costs which is imposed on the families and insurance organizations. This study was conducted to determine the efficacy of epinephrine in comparison with salbutamol in the treatment of the disease.
Methods: Forty infants aged one month to 2 years with acute bronchiolitis in Amin and Al-Zahra hospitals, during 2008, were enrolled in this study. The participants were randomized in two treatment groups to receive epinephrine 0.1 ml/kg or salbutamol 0.15 mg/kg. Three doses of each medication were prescribed at intervals of 20 minutes and continued every 10 minutes after the third dose. The patients in both groups were monitored and rated by RDAI, number of the hospitalized days in the hospital, level of oxygen saturation and vital signs.
Findings: Mean hospitalization duration was 3.3±1.1 and 3±0.9 in the patients receiving salbutamol and epinephrine, respectively (P=0.03). There was a significant difference in assessing RDAI index between the two groups (P=0.03). There were no differences in SPO2, PR, or RR variables in the studied intervals in both groups (P>0.05).
Conclusion: Regarding the effect of epinephrine on reduction of hospitalization duration and the RDAI index in patients with acute bronchiolitis, it seems that using epinephrine instead of salbutamol could be more effective in the management of the disease.

Keywords

Upper Respiratory Infections

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