Hearing Impairment in Congenitally Hypothyroid Patients

Roya Kelishadi; Somaye Sadeghi; Massoud Amini; Mostafa Hashemi; Mahin Hashemipour; Silva Hovsepian

IJ Pediatrics

The Scientific Journal of Growth & Development Research Center

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Hearing Impairment in Congenitally Hypothyroid Patients

Author(s):

Roya Kelishadi¹,

Somaye Sadeghi²,

Massoud Amini²,

Mostafa Hashemi³,

Mahin Hashemipour⁴,

Silva Hovsepian^4,*

1Child Health Promotion Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

2Endocrine & Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

3Endocrine & Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Andorra

4Endocrine & Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan & Child Health Promotion Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

IJ Pediatrics:Vol. 22, issue 1; 92-96

Published online:Mar 31, 2012

Article type:Research Article

Received:Dec 22, 2010

Accepted:May 06, 2011

How to Cite:Roya KelishadiSomaye SadeghiMassoud AminiMostafa HashemiMahin HashemipourSilva Hovsepianet al.Hearing Impairment in Congenitally Hypothyroid Patients.Iran J Pediatr.22(1):92-96.

Abstract

Objective: Thyroid hormone is necessary for normal development of the auditory system. The aim of this study was to investigate the rate of hearing impairment in congenitally hypothyroid (CH) patients, and its relation with factors such as CH severity and age at starting treatment, during CH screening program in Isfahan.
Methods: Hearing acuity was assessed in two groups of children with (94 patients aged 4 months – 3 years) and without CH (450), between 2000-2006. Otoacostic emission (OAE) was performed by a two step method. After two tests without OAE signals bilaterally, they were referred for auditory brainstem response (ABR) test. Subjects with both OAE and ABR abnormal test results were considered to have hearing problem. Obtained data was compared in case and control group and also CH patients with and without hearing impairment.
Findings: Three (3.2%) of patients and 1 of control group (0.2%) were diagnosed with sensorineural hearing loss. The rate of hearing loss was not different significantly in two studied groups (P>0.05). There was no difference between age of starting treatment and first T4 and TSH level in CH patients with and without hearing loss (P>0.05). CH neonates with hearing impairment had thyroid dyshormonogenesis according to the follow up results.
Conclusion: The rate of hearing loss was low among our studied CH patients. It may be due to proper management of CH patients. In view of the fact that all CH neonates were dyshormonogentic and considering the relation between certain gene mutations and hearing impairment in CH patients, further studies with larger sample size, with regard to different etiologies of CH should be investigated to indicate the possible gene mutations related to hearing loss in CH.

Keywords

Hearing impairment

Auditory Brain Stem Response

ABR

Oto Acostic Emission

OAE

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