Pericardial Effusion and Atrial Thrombosis: A Rare Complication of Childhood Leukemia

Ahmad Jannati; Mohammadreza Farahmandfar; Maral Namdari; Sirous Cheriki; Soheila Zareifar

IJ Pediatrics

The Scientific Journal of Growth & Development Research Center

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Pericardial Effusion and Atrial Thrombosis: A Rare Complication of Childhood Leukemia

Author(s):

Ahmad Jannati¹,

Mohammadreza Farahmandfar²,

Maral Namdari²,

Sirous Cheriki³,

Soheila Zareifar^2,*

1Department of Pediatrics, Shiraz University of Medical Sciences, Shiraz, Iran

2Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

3Cardiac Department, Shiraz University of Medical Sciences, Shiraz, Iran

IJ Pediatrics:Vol. 22, issue 1; 117-120

Published online:Mar 31, 2012

Article type:Case Report

Received:Sep 15, 2010

Accepted:Jul 19, 2011

How to Cite:Ahmad JannatiMohammadreza FarahmandfarMaral NamdariSirous CherikiSoheila ZareifarPericardial Effusion and Atrial Thrombosis: A Rare Complication of Childhood Leukemia.Iran J Pediatr.22(1):117-120.

Abstract

Background: Acute lymphoblastic leukemia (ALL) is the most common malignancy diagnosed in children. Extramedullary leukemia including hepatosplenomegaly, lymphadenopathy, and mediastinal mass are the clinical presentations of T-cell ALL. Pericardial effusion and atrial mass are rare presentations of pediatric leukemia.
Case Presentation: We report a 15-year-old girl with T-cell ALL, who presented initially with pericardial effusion and cardiac tamponade and subsequently developed right atrial mass. The mediastinal and right atrial masses were excised by surgical procedure as a treatment strategy for prevention of arrhythmia and sudden death.
Conclusion: T-cell ALL can present with pericardial and mediastinal involvement as an initial manifestation. Pericardiocenthesis and systemic anticancer chemotherapy without local chemotherapy should be considered in these cases.

Keywords

Acute Lymphoblastic Leukemia

Extramedullary Leukemia

Pericardial Effusion

Atrial Mass

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