Evaluation of the Growth Process of Infants Conceived by Assisted Reproductive Techniques at Royan Institute from Birth to 9 Months

Abolhasan Shahzadehfazeli; Leila Nedaifard; Mohammad-Reza Nateghi; Jalil Kouhpayezadeh; Shabnam Zoljalali; Ramin Mozafari Kermani

IJ Pediatrics

The Scientific Journal of Growth & Development Research Center

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Evaluation of the Growth Process of Infants Conceived by Assisted Reproductive Techniques at Royan Institute from Birth to 9 Months

Author(s):

Abolhasan Shahzadehfazeli¹,

Leila Nedaifard²,

Mohammad-Reza Nateghi²,

Jalil Kouhpayezadeh²,

Shabnam Zoljalali²,

Ramin Mozafari Kermani^2,*

1Genetics Department, Royan Institute for Reproductive Biomedicine, Tehran, Iran

2Child Health Research Department, Iran Medical Sciences Branch of Academic Center for Education, Culture and Research, Tehran, Iran

IJ Pediatrics:Vol. 22, issue 1; 449-454

Published online:Dec 31, 2011

Article type:Research Article

Received:May 21, 2010

Accepted:Mar 15, 2011

How to Cite:Abolhasan ShahzadehfazeliLeila NedaifardMohammad-Reza NateghiJalil KouhpayezadehShabnam ZoljalaliRamin Mozafari Kermaniet al.Evaluation of the Growth Process of Infants Conceived by Assisted Reproductive Techniques at Royan Institute from Birth to 9 Months.Iran J Pediatr.22(1):449-454.

Abstract

Objective: Due to recent scientific progress in assisted reproductive techniques (ART), infertile couples can now become fertile. Thus, a number of infants in our country are the results of these costly interventions. This study has been undertaken to evaluate the physical growth process of different methods of ART infants by standard growth charts from birth until nine months of age.
Methods: This was a descriptive cross-sectional study of 333 infants conceived through ART [intracytoplasmic sperm injection (ICSI) and in vitro fertilization (IVF)] at Royan Institute. A sequential, non-random sampling method in a period of 22 months was used. Their growth was assessed by measuring infants' weight, height and head circumference, and physical examination. The growth patterns were calculated by recording the values in standard growth charts. The final analysis was done with SPSS version 16 and by using Chi-square test.
Findings: In comparison with growth charts, the weights of one-third of the infants were less than two standard deviations (SD) at birth and one-fourth had head circumference less than three SD at birth. Low birth weight (LBW) infants were six times more than infants of normal population. From birth to six months of age, growth abnormalities were seen in a substantial number of infants. However, at nine months of age, there was no significant difference observed between infants conceived by different methods of ART (IVF and ICSI).
Conclusion: Multiple births are the most important confounding factor impacting the growth process of ART infants. Multiple pregnancies can lead to low birth weight, height and head circumference, and growth abnormalities up to six months of age. This abnormality improves by increasing age of the infants.

Keywords

Assisted reproductive techniques

Low birth weight

Growth index

in vitro fertilization

intracytoplasmic sperm injection

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