Diagnostic Value of Serum Procalcitonin Level in Differentiating Bacterial from Nonbacterial Meningitis in Children

Raid M.R.  Umran; Nabeel  Hashim Radhi

IJ Pediatrics

The Scientific Journal of Growth & Development Research Center

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Diagnostic Value of Serum Procalcitonin Level in Differentiating Bacterial from Nonbacterial Meningitis in Children

Author(s):

Raid M.R. Umran^1,*,

Nabeel Hashim Radhi²

IJ Pediatrics:Vol. 24, issue 6; 739-744

Published online:Dec 09, 2014

Article type:Research Article

Received:May 03, 2014

Accepted:Jul 18, 2014

How to Cite:Raid M.R. UmranNabeel Hashim RadhiDiagnostic Value of Serum Procalcitonin Level in Differentiating Bacterial from Nonbacterial Meningitis in Children.Iran J Pediatr.24(6):739-744.

Abstract

Objective: Acute bacterial meningitis in pediatrics remains a serious and potentially lethal disease. Its prognosis is critically dependent on rapid diagnosis and treatment. The use of biological markers, like procalcitonin, has been proposed to facilitate the accuracy of the initial diagnosis of bacterial meningitis. The aim of this study was assessment the diagnostic values of serum procalcitonin (PCT) assay in the diagnosis and differentiation of acute bacterial from non bacterial meningitis. Methods: 45 patients with suspicion of meningitis were enrolled in the study and were clinically evaluated and investigated by lumbar punctures for cerebrospinal fluid analysis, C-reactive protein and differential leukocyte count. Patients with clinical and laboratory suggestion of bacterial causes were regarded as bacterial meningitis group (29 patients), and those who were suggestive of nonbacterial causes were regarded as nonbacterial group (16 patients). Findings: Serum procalcitonin levels were significantly higher in bacterial meningitis group (637±325 pg/ml) compared with non-bacterial meningitis (380±170 pg/ml); P

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