Safety and Efficacy of Phenylephrine Nasal Drops in Bronchiolitis

Gholamreza  Soleimani; Marzieh  Akbarpour; Mehdi  Mohammadi

IJ Pediatrics

The Scientific Journal of Growth & Development Research Center

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Safety and Efficacy of Phenylephrine Nasal Drops in Bronchiolitis

Author(s):

Gholamreza Soleimani^1,*,

Marzieh Akbarpour²,

Mehdi Mohammadi³

IJ Pediatrics:Vol. 24, issue 5; 593-597

Published online:Oct 05, 2014

Article type:Research Article

Received:Nov 14, 2013

Accepted:Jun 25, 2013

How to Cite:Gholamreza SoleimaniMarzieh AkbarpourMehdi MohammadiSafety and Efficacy of Phenylephrine Nasal Drops in Bronchiolitis.Iran J Pediatr.24(5):593-597.

Abstract

Objective: Bronchiolitis is a common lower respiratory tract infection in the first year of life. In this disease upper respiratory tract infection is associated with nasal congestion, respiratory distress and hypoxia. We studied the effect of phenylephrine drops as a decongestant in treatment of light and moderately severe cases of acute bronchiolitis. Methods: This is a double blind randomized trial involving 100 children aged 4 weeks to 12 months. The patients were divided into two groups, the first group received 0.1 ml phenylephrine 0.5% and the second group 0.1 ml sodium chloride (NaCl) 0.9% as placebo in both nostrils. Respiratory rate, heart rate, O2 saturation, dyspnea, retractions and wheezing were assessed before and 30 minutes after medication. Findings: After medication, O2 saturation and respiratory muscles retractions in the phenylephrine group were significantly better than those of the placebo group (P=0.004 and P=0.002, respectively). In the phenylephrine group, O2 saturation, retractions and wheezing were also significantly better before than those after medication (P=0.003 and P

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