Effects of Metoclopramide on Feeding Intolerance among Preterm Neonates; A Randomized Controlled Trial

Mirhadi Mussavi; Khairollah Asadollahi; Ghobad  Abangah

IJ Pediatrics

The Scientific Journal of Growth & Development Research Center

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Effects of Metoclopramide on Feeding Intolerance among Preterm Neonates; A Randomized Controlled Trial

Author(s):

Mirhadi Mussavi^1,*,

Khairollah Asadollahi²,

Ghobad Abangah³

IJ Pediatrics:Vol. 24, issue 5; 630-636

Published online:Oct 28, 2014

Article type:Research Article

Received:Jan 13, 2014

Accepted:Jun 12, 2014

How to Cite:Mirhadi MussaviKhairollah AsadollahiGhobad AbangahEffects of Metoclopramide on Feeding Intolerance among Preterm Neonates; A Randomized Controlled Trial.Iran J Pediatr.24(5):630-636.

Abstract

Objective: To evaluate the efficacy and safety of metoclopramide in the treatment of feeding intolerance in preterm neonates less than 36 weeks of gestational age. Methods: A randomized, controlled, masked cross-over study. A block of 4 randomizations was used. The “drug group” received intravenous metoclopramide before feeding and placebo group received placebo at the same time. The time to full enteral feeding and suspected adverse effects of metoclopramide, length of hospital stay or incidence of NEC or septicemia were the main outcome measures. Findings: Mean (standard deviation) of weight and Apgar score among metoclopramide and placebo groups were 1638.3±321 gr, 8.9±1.4 and 1593.3±318.8 gr, 8.8±1.3 respectively. Times to full feeding were significantly shorter in the metoclopramide group than in the control group (12.9±5.6 vs 17.0±6.3; P

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