Treatment of Cutaneous Injuries of Neonates Induced by Drug Extravasation with Hyaluronidase and Hirudoid

Ya-Min Yan; Qiao-Ling Fan; Ai-Qiu Li; Jia-Ling Chen; Fei-Fei Dong; Mei Gong

IJ Pediatrics

The Scientific Journal of Growth & Development Research Center

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Treatment of Cutaneous Injuries of Neonates Induced by Drug Extravasation with Hyaluronidase and Hirudoid

Author(s):

Ya-Min Yan¹,

Qiao-Ling Fan²,

Ai-Qiu Li³,

Jia-Ling Chen⁴,

Fei-Fei Dong⁵,

Mei Gong^6,*

IJ Pediatrics:Vol. 24, issue 4; 345-351

Published online:Jul 03, 2014

Article type:Research Article

Received:Jul 04, 2013

Accepted:May 14, 2014

How to Cite:Ya-Min YanQiao-Ling FanAi-Qiu LiJia-Ling ChenFei-Fei DongMei Gonget al.Treatment of Cutaneous Injuries of Neonates Induced by Drug Extravasation with Hyaluronidase and Hirudoid.Iran J Pediatr.24(4):345-351.

Abstract

Objective: To analyze the effects of hyaluronidase and hirudoid treatment on drug extravasation in neonates.Methods: The medical records of 13 neonates with drug extravasation treated with hyaluronidase and hirudoid between August 1st, 2010 and May 1st, 2012 were analyzed retrospectively. The treatment procedure for drug extravasation adhered to the protocol in neonatal department. The information including age, sex, weight, diagnosis, size of affected area, site of extravasation and treatment was collected.Findings: The extravasation injuries alleviated and the symptoms improved after treatment, no adverse drug effects were reported with use of hyaluronidase and hirudoid.Conclusion: The treatment appeared to be beneficial in the management of extravasations of various medications in neonates and may be useful in reducing the severity of cutaneous toxicosis. However, further studies with large samples are still needed to assess the effectiveness and safety of hyaluronidase and hirudoid.

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