Distribution and Protective Role of HLAB40 in Iranian Patients with Kawasaki Disease; a Report from Southern Iran

Gholamhossein  Ajami; Khashayar  Aflaki; Behrooz  Gharesi-fard; Mohammad  Borzouee; Hamid  Amoozgar

IJ Pediatrics

The Scientific Journal of Growth & Development Research Center

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Distribution and Protective Role of HLAB40 in Iranian Patients with Kawasaki Disease; a Report from Southern Iran

Author(s):

Gholamhossein Ajami¹,

Khashayar Aflaki²,

Behrooz Gharesi-fard³,

Mohammad Borzouee⁴,

Hamid Amoozgar^5,*

IJ Pediatrics:Vol. 24, issue 4; 359-364

Published online:May 24, 2014

Article type:Research Article

Received:Oct 07, 2013

Accepted:May 14, 2014

How to Cite:Gholamhossein AjamiKhashayar AflakiBehrooz Gharesi-fardMohammad BorzoueeHamid AmoozgarDistribution and Protective Role of HLAB40 in Iranian Patients with Kawasaki Disease; a Report from Southern Iran.Iran J Pediatr.24(4):359-364.

Abstract

Objective: Kawasaki disease (KD) clinically presents as a systemic vasculitis syndrome with significant cardiovascular involvement. With different incidence among different ethnic groups, the role of certain human leukocyte antigens and their products has been considered as a crucial predisposing factor in the immune responses in this disease.Methods: We determined the distribution of human leukocyte antigens type B for 90 Iranian patients with Kawasaki disease in order to evaluate a possible association between these antigens and this disease in our area. We used the polymerase chain reaction (PCR) sequence specific primers (PCR-SSP) technique for antigen typing. Distribution of these antigens for 89 healthy Iranians used as control.Findings: While 7 (3.9%) of our patients were positive for human leukocyte antigen type B 40*, there were 18 (10.1%) subjects from the control group who had this antigen with statistically significant difference between patients and control group (CI= 95%, RR=1.15 and P= 0.02). Data were analyzed by Pearson chi-square test and Fisher's exact test. SPSS version 15 was used for statistical analysis and a P value less than 0.05 considered statistically significantConclusion: The presence of higher frequency of allele type-B40* in the control group may represent a protective role for this antigen with resultant decreased susceptibility to KD in our area.

Keywords

Kawasaki Disease

Gene Protection

Human Leukocyte Antigens

HLA- B40* Allele

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