The Effect of Malnutrition on Protein Glycosylation in Children

Oznur  Bilen; Zekiye  Altun; Nur  Arslan; Banu  Onvural; Pinar  Akan; Canan  Coker

IJ Pediatrics

The Scientific Journal of Growth & Development Research Center

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The Effect of Malnutrition on Protein Glycosylation in Children

Author(s):

Oznur Bilen¹,

Zekiye Altun²,

Nur Arslan^3,*,

Banu Onvural⁴,

Pinar Akan⁵,

Canan Coker⁶

IJ Pediatrics:Vol. 24, issue 3; 273-279

Published online:Apr 07, 2014

Article type:Research Article

Received:Apr 15, 2013

Accepted:Feb 08, 2014

How to Cite:Oznur BilenZekiye AltunNur ArslanBanu OnvuralPinar AkanCanan Cokeret al.The Effect of Malnutrition on Protein Glycosylation in Children.Iran J Pediatr.24(3):273-279.

Abstract

Objective: The goal of this study was to evaluate the effect of protein energy malnutrition on protein glycosylation by investigating transferrin isoform pattern and its relationship to the degree of malnutrition and the biochemical markers of nutritional status in children. Methods: Forty one children with mild (n=23) and severely/moderately (n=18) acute malnutrition and 29 controls were enrolled in the study. Serum transferrin isoforms were determined by isoelectric focusing electrophoresis. Transferrin, prealbumin, zinc, iron and insulin-like growth factor-1 (IGF-1) were measured using automated analyzers.Findings: Asialotransferrin and disialotransferrin were significantly higher in severely/moderately malnourished patients compared to controls (P=0.04 and P=0.04, respectively). Other transferrin isoform patterns were not different among three groups. Serum IGF-1, transferrin and iron levels of severely/ moderately malnourished group were significantly lower than tose of controls (P=0.001, 0.02 and 0.03, respectively). Serum prealbumin and zinc levels were similar in all three groups. Serum IGF-1, transferrin and iron levels, and all transferrin isoform patterns were not significantly different in mildly malnutrition group from other two groups.Conclusion: The changes in transferrin isoform pattern observed in malnourished patients may indicate that malnutrition is a catabolic state which has effects on glycosylation.

Keywords

Glycosylation

Isoelectric Focusing

Protein Energy Malnutrition

Transferrin

Isoform

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