Absence of Association between -1131T>C Polymorphism in the Apolipoprotein APOA5 Gene and Pediatric Metabolic Syndrome

authors:

avatar Sayedeh Ghazaleh Fatemi 1 , avatar Modjtaba Emadi-Baygi 2 , avatar Parvaneh Nikpour 3 , * , avatar Roya Kelishadi 4 , avatar Mahin Hashemipour 5

Iranian Journal of Pediatrics: Vol.24, issue 3; 319-322
published online: May 08, 2014
article type: Rapid Communication
received: June 24, 2013
accepted: January 29, 2014

how to cite: Fatemi S G , Emadi-Baygi M, Nikpour P , Kelishadi R , Hashemipour M . Absence of Association between -1131T>C Polymorphism in the Apolipoprotein APOA5 Gene and Pediatric Metabolic Syndrome. Iran J Pediatr. 2014;24(3): 319-322. 

Abstract

Objective: In the present study, we evaluated the association of rs662799 variant of the APOA5 gene with Metabolic syndrome (MetS) in a sample of children and adolescents from Isfahan.Methods: This case control study comprised 50 cases of MetS and 50 controls. Mismatched polymerase chain reaction–restriction fragment length polymorphism (mPCR-RFLP) was used to genotype -1131T>C polymorphism.Findings: No significant association was documented for APOA5 genotypes with the measured laboratory parameters for CC, CT, and TT genotypes in the two groups studied. By logistic regression using a dominant model, the odds ratio (95% confidence interval0 for the MetS was 0.38 (0.139–1.0350 and 0.29 (0.08–1.071 for the unadjusted and adjusted models, respectively.Conclusion: This study suggests that among studied children and adolescents, -1131T>C polymorphism in the APOA5 gene may not be a major contributor to the MetS risk.
 

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