A Randomized Clinical Trial of Insulin Glargine and Aspart, Compared to NPH and Regular Insulin in Children with Type 1 Diabetes Mellitus

Aria  Setoodeh; Parastoo Rostami; Ali Rabbani; Maryam Nakhaei-Moghadam; Farnaz Najmi-Varzaneh; Nima Rezaei

IJ Pediatrics

The Scientific Journal of Growth & Development Research Center

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A Randomized Clinical Trial of Insulin Glargine and Aspart, Compared to NPH and Regular Insulin in Children with Type 1 Diabetes Mellitus

Author(s):

Aria Setoodeh^1,*,

Parastoo Rostami²,

Ali Rabbani³,

Maryam Nakhaei-Moghadam⁴,

Farnaz Najmi-Varzaneh⁵,

Nima Rezaei⁶

IJ Pediatrics:Vol. 24, issue 2; 173-178

Published online:Feb 15, 2014

Article type:Research Article

Received:Feb 24, 2013

Accepted:Dec 25, 2013

How to Cite:Aria SetoodehParastoo RostamiAli RabbaniMaryam Nakhaei-MoghadamFarnaz Najmi-VarzanehNima Rezaeiet al.A Randomized Clinical Trial of Insulin Glargine and Aspart, Compared to NPH and Regular Insulin in Children with Type 1 Diabetes Mellitus.Iran J Pediatr.24(2):173-178.

Abstract

Objective: Appropriate treatment of patients with Type 1 diabetes mellitus (T1DM) is necessary to avoid further complications. This study was performed to compare the efficacy of insulin Glargine and Aspart with NPH insulin and regular insulin regimen in a group of children with T1DM. Methods: Forty patients with T1DM were enrolled in this study. During run-in, all subjects were treated with conventional therapy consisting of twice-daily NPH and thrice-daily regular. Following randomization, 20 subjects received Glargine and Aspart and 20 subjects received NPH and Regular insulin. Findings: Mean HbA1c was 8.8% and 8.6% at first and 8.4% and 8.2% at the end of study for subjects randomized initially to Glargine and Aspart and for those randomized to NPH and Regular, respectively (P>0.05). Mean fasting blood glucose (FBS) of the subjects randomized initially to Glargine and Aspart was 217±101 mg/dL, with no significant difference to 196±75 mg/dL for those randomized to NPH and Regular (P=0.48). This was also true at the end of the study. The difference in total cholesterol and triglyceride between the two groups in the beginning of study and at the end did not show any significance. Conclusion: The current study showed no significant difference in glycemic control [Glycated hemoglobin (HbA1c) and FBS] and lipid profile (total cholesterol and triglyceride) between two regimes.

Keywords

Type 1 Diabetes Mellitus

Insulin Glargine

Insulin Aspart

Conventional Therapy

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