Risk Factors of Germinal Matrix Intraventricular Hemorrhage in Premature Infants

authors:

avatar Yeliz Pekcevik 1 , * , avatar Aynur Pasinli 2 , avatar Esra Arun Ozer 3 , avatar Nuri Erdogan 4

Iranian Journal of Pediatrics: Vol.24, issue 2; 191-197
published online: January 29, 2014
article type: Research Article
received: June 14, 2013
accepted: January 10, 2014

How To Cite Pekcevik Y, Pasinli A , Arun Ozer E, Erdogan N. Risk Factors of Germinal Matrix Intraventricular Hemorrhage in Premature Infants. Iran J Pediatr. 2014;24(2): 191-197. 

Abstract

Objective: To determine whether some clinical parameters can be used to predict the hemorrhage and whether the relationship between these clinical variables and the grades of hemorrhage is linear. Methods: A total of 230 premature infants, born at a gestational age less than 34 weeks were retrospectively reviewed. Germinal matrix-intraventricular hemorrhage (GM-IVH), the grade of the hemorrhage, and clinical data were assessed with a checklist. Variables were analyzed by using Mann Whitney U and Fisher's exact tests and then multiple logistic regression analysis was used to evaluate the independent risk factors. Findings: Resuscitation, gestational age, hypotension, multiple birth, and birth weight were found to be independent risk factors. We determined non-linear relationship between the grades of hemorrhage and the clinical parameters. But when we classified hemorrhages as grade 1, grade 2-3 and grade 4, the relationships were found linear. Conclusion: Premature infants who had resuscitation, low gestational age, hypotension, multiple birth, and low birth weight are more likely to have GM-IVH. The relationship between the clinical variables and the grades of GM-IVH does not seem to be linear.
 

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